Vitamin E may slow Alzheimer's disease progression (BLOG)

<div dir="ltr" style="text-align: left;" trbidi="on"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjAkTQVASxNvNuvdthgag6WMfXCYxyJ39NWRshmaEtH81_TJacnbI6uXmtK8xRUvw9JWqsRRUMRwDI1J2toauDQBaCCvpWaUop4Hys4xWpuS_EAcfnvZ6yR3tMTWa-iIbQVSCLtv-TUAuY/s1600/fa45926212b4852c470f6a706700028f.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="213" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjAkTQVASxNvNuvdthgag6WMfXCYxyJ39NWRshmaEtH81_TJacnbI6uXmtK8xRUvw9JWqsRRUMRwDI1J2toauDQBaCCvpWaUop4Hys4xWpuS_EAcfnvZ6yR3tMTWa-iIbQVSCLtv-TUAuY/s320/fa45926212b4852c470f6a706700028f.jpg" width="320" /></a></div><div id="yui_3_9_1_1_1388631697698_9133" style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Researchers say vitamin E might slow the progression of mild-to-moderate Alzheimer's disease — the first time any treatment has been shown to alter the course of dementia at that stage.</div><div class="body-slot-mod" style="background-color: white; clear: right; float: right; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 12px; line-height: 18px; margin: 0px 0px 1.1em 10px; max-width: 300px;"><div class="yom-remote"><div class="" id="mediacontentrelatedstory_container"><section class="yom-mod " data-ylk="mid:mediacontentrelatedstory;mpos:1;elm:hdln;elmt:ct;cat:Related Stories;rspns:nav;t1:a3;itc:0;sec:lst-ct;" id="mediacontentrelatedstory" style="margin: 0px; padding: 0px;"></section></div></div></div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">In a study of more than 600 older veterans, high doses of the vitamin delayed the decline in daily living skills, such as making meals, getting dressed and holding a conversation, by about six months over a two-year period.</div><div id="yui_3_9_1_1_1388631697698_9138" style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">The benefit was equivalent to keeping one major skill that otherwise would have been lost, such as being able to bathe without help. For some people, that could mean living independently rather than needing a nursing home.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Vitamin E did not preserve thinking abilities, though, and it did no good for patients who took it with another Alzheimer's medication. But those taking vitamin E alone required less help from caregivers — about two fewer hours each day than some others in the study.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">"It's not a miracle or, obviously, a cure," said study leader Dr. Maurice Dysken of the Minneapolis VA Health Care System. "The best we can do at this point is slow down the rate of progression."</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">The U.S. Department of Veterans Affairs sponsored the study, published Tuesday by the Journal of the American Medical Association.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">No one should rush out and buy vitamin E, several doctors warned. It failed to prevent healthy people from developing dementia or to help those with mild impairment ("pre-Alzheimer's") in other studies, and one suggested it might even be harmful.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Still, many experts cheered the new results after so many recent flops of once-promising drugs.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">"This is truly a breakthrough paper and constitutes what we have been working toward for nearly three decades: the first truly disease-modifying intervention for Alzheimer's," said Dr. Sam Gandy of Mount Sinai School of Medicine in New York. "I am very enthusiastic about the results."</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. There is no cure and current medicines just temporarily ease symptoms.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Researchers don't know how vitamin E might help, but it is an antioxidant, like those found in red wine, grapes and some teas. Antioxidants help protect cells from damage that can contribute to other diseases, says the federal Office on Dietary Supplements. Many foods contain vitamin E, such as nuts, seeds, grains, leafy greens and vegetable oils. There are many forms, and the study tested a synthetic version of one — alpha-tocopherol — at a pharmaceutical grade and strength, 2,000 international units a day.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Years ago, another study found that the same form and dose helped people with more advanced Alzheimer's, and many were prescribed it. But vitamin E fell out of favor after a 2005 analysis of many studies found that those taking more than 400 units a day were more likely to die of any cause.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">The new study involved 613 veterans, nearly all male, 79 years old on average, with mild to moderate Alzheimer's, at 14 VA centers. All were already taking Aricept, Razadyne or Exelon — widely used, similar dementia medicines.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Participants were placed in four groups and given either vitamin E, another dementia medicine called memantine (its brand name is Namenda), both pills or dummy pills.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">After a little more than two years of follow-up, those on vitamin E alone had a 19 percent lower annual rate of decline in daily living skills compared to the placebo group. Memantine made no difference, and vitamin E did not affect several tests of thinking skills.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">"It's a subtle effect but it's probably real," Dr. Ron Petersen, the Mayo Clinic's Alzheimer's research chief, said of the benefit on daily living from vitamin E. "That has to be weighed against the potential risks" seen in earlier studies, he said.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Heather Snyder, director of medical and scientific operations for the Alzheimer's Association, said the group's position is that "no one should take vitamin E for Alzheimer's disease or other memory issues except under the supervision of a physician," because it can interfere with blood thinners, cholesterol drugs and other medicines.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">The new results also need to be verified in a fresh study that includes more women and minorities, she said.</div><div style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">___</div><div id="yui_3_9_1_1_1388631697698_9152" style="background-color: white; font-family: 'Helvetica Neue', HelveticaNeue, helvetica, arial, sans-serif; font-size: 15px; line-height: 24px; margin-bottom: 1.1em;">Follow Marilynn Marchione on Twitter at http://twitter.com/MMarchioneAP</div></div>

Vitamin E may slow Alzheimer's disease progression (BLOG)

Researchers say vitamin E might slow the progression of mild-to-moderate Alzheimer's disease — the first time any treatment has been sho...

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