Price for a New Hip? Many Hospitals Are Stumped - NYTimes.com

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Jaime Rosenthal, a senior at Washington University in St. Louis, called more than 100 hospitals in every state last summer, seeking prices for a hip replacement for a 62-year-old grandmother who was uninsured but had the means to pay herself.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The quotes she received might surprise even hardened health care economists: only about half of the hospitals, including top-ranked orthopedic centers and community hospitals, could provide any sort of price estimate, despite repeated calls. Those that could gave quotes that varied by a factor of more than 10, from $11,100 to $125,798.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Ms. Rosenthal's grandmother was fictitious, created for a summer research project on health care costs. But the findings, which form the basis of a paper released on Monday by JAMA Internal Medicine, are likely to fan the debate on the unsustainable growth of American health care costs and an opaque medical system in which prices are often hidden from consumers.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"Transparency is all the rage these days in government and business, but there has been little push for pricing transparency in health care, and there's virtually no information," said Dr. Peter Cram, an associate professor of internal medicine at the University of Iowa, who wrote the paper with Ms. Rosenthal. He added: "I can get the price for a car, for a can of oil, for a gallon of milk. But health care? That's not so easy."</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">President Obama's Affordable Care Act focused primarily on providing insurance to Americans who did not have it. But the high price of care remains an elephant in the room. Although many experts have said that Americans must become more discerning consumers to help rein in costs, the study illustrates how hard that can be.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"We've been trying to help patients get good value, but it is really hard to get price commitments from hospitals - we see this all the time," said Jeff Rice, the chief executive of Healthcare Blue Book, a company that collects data on medical procedures, doctors visits and tests. "And even if they say $20,000, it often turns out $40,000 or 60,000."</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">There are many caveats to the study. Most patients - or insurers - never pay the full sticker price of surgery, because insurance companies bargain with hospitals and doctors for discounted rates. When Ms. Rosenthal balked at initial high estimates, some hospitals produced lower rates for a person without insurance.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">But in other ways the telephone quotations underestimated prices, because they did not include the fees for outpatient rehabilitation, for example.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">In an accompanying commentary, Andrew Steinmetz and Ezekiel J. Emanuel of the University of Pennsylvania acknowledged that there was "no justification" for the inability to provide estimates or for the wide range of prices. But they said that more rigorous data on quality - like infection rates and unexpected deaths - were required to know when high prices were worth it.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"Without quality data to accompany price data, physicians, consumers and other health care decision makers have no idea if a lower price represents shoddy quality of if it constitutes good value," they wrote.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">But, broadly, researchers emphasized that studies had found little consistent correlation between higher prices and better quality in American health care. Dr. Cram said there was no data that "Mercedes" hip implants were better than cheaper options, for example.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Jamie Court, the president of the California-based Consumer Watchdog, said: "If one hospital can put in a hip for $12,000, then every hospital should be able to do it. When there's 100 percent variation in sticker price, then there is no real price. It's about profit."</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Dr. Cram said the study did contain some good news: some of the country's top-ranked hospitals came up with "bargain basement prices" in response to repeated calls. "If you're a good consumer and shop around, you can get a good price - you don't have to pay $120,000 for a Honda," he said.</div><div style="color: rgb(51, 51, 51); font-size: medium; margin-top: 0px; margin-right: 0px; margin-bottom: 0.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; line-height: 1.375em; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); position: static; z-index: auto; ">But that shopping can be arduous in a market not set up to respond to consumers. To get a total price, Ms. Rosenthal often had to call the hospital to get its estimate for on-site care, and a separate quote from doctors. And many were simply perplexed when she asked for a price upfront, Ms. Rosenthal said, adding, "The people who answered didn't know what to do with the question."</div></div><a href="http://well.blogs.nytimes.com/2013/02/11/price-for-a-new-hip-many-hospitals-are-stumped/?pagewanted=print">http://well.blogs.nytimes.com/2013/02/11/price-for-a-new-hip-many-hospitals-are-stumped/?pagewanted=print</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><br class="webkit-block-placeholder"></div>

Price for a New Hip? Many Hospitals Are Stumped - NYTimes.com

Jaime Rosenthal, a senior at Washington University in St. Louis, called more than 100 hospitals in every state last summer, seeking prices for a hip replacement for a 62-year-old grandmother who was uninsured but had the means to pay herself.The quot…

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Health Testing on Mice Is Found Misleading in Some Cases - NYTimes.com

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">For decades, mice have been the species of choice in the study of human diseases. But now, researchers report evidence that the mouse model has been totally misleading for at least three major killers — <a href="http://health.nytimes.com/health/guides/disease/sepsis/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Sepsis." class="meta-classifier" style="color: rgb(102, 102, 153); text-decoration: none; ">sepsis</a>, burns and trauma. As a result, years and billions of dollars have been wasted following false leads, they say.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The study's findings do not mean that mice are useless models for all human diseases. But, its authors said, they do raise troubling questions about diseases like the ones in the study that involve the immune system, including <a href="http://health.nytimes.com/health/guides/disease/cancer/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Cancer." class="meta-classifier" style="color: rgb(102, 102, 153); text-decoration: none; ">cancer</a> and heart disease.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"Our article raises at least the possibility that a parallel situation may be present," said <a href="http://www2.massgeneral.org/id/faculty/research_interests/index.asp?ID=33" style="color: rgb(102, 102, 153); text-decoration: none; ">Dr. H. Shaw Warren</a>, a sepsis researcher at Massachusetts General Hospital and a lead author of the new study.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); "><a href="http://www.pnas.org/cgi/doi/10.1073/pnas.1222878110" style="color: rgb(102, 102, 153); text-decoration: none; ">The paper</a>, published Monday in <a href="http://www.pnas.org/" style="color: rgb(102, 102, 153); text-decoration: none; ">Proceedings of the National Academy of Sciences</a>, helps explain why every one of nearly 150 drugs tested at a huge expense in patients with sepsis has failed. The drug tests all were based on studies in mice. And mice, it turns out, can have something that looks like sepsis in humans, but is very different from the condition in humans.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Medical experts not associated with the study said that the findings should change the course of research worldwide for a deadly and frustrating condition. Sepsis, a potentially deadly reaction that occurs as the body tries to fight an infection, afflicts 750,000 patients a year in the United States, kills one-fourth to one-half of them, and costs the nation $17 billion a year. It is the leading cause of death in intensive-care units.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"This is a game changer," said Dr. Mitchell Fink, a sepsis expert at the University of California, Los Angeles, of the new study.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"It's amazing," said Dr. Richard Wenzel, a former chairman at the department of internal medicine at Virginia Commonwealth University and a former editor of The New England Journal of Medicine. "They are absolutely right on."</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Potentially deadly immune responses occur when a person's immune system overreacts to what it perceives as danger signals, including toxic molecules from bacteria, viruses, fungi, or proteins released from cells damaged by trauma or burns, said Dr. Clifford S. Deutschman, who directs sepsis research at the University of Pennsylvania and was not part of the study.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The ramped-up immune system releases its own proteins in such overwhelming amounts that capillaries begin to leak. The leak becomes excessive, and serum seeps out of the tiny blood vessels.<a href="http://health.nytimes.com/health/guides/test/blood-pressure/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Blood Pressure." class="meta-classifier" style="color: rgb(102, 102, 153); text-decoration: none; ">Blood pressure</a> falls, and vital organs do not get enough blood. Despite efforts, doctors and nurses in an intensive-care unit or an emergency room may be unable to keep up with the leaks, stop the infection or halt the tissue damage. Vital organs eventually fail.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The new study, which took 10 years and involved 39 researchers from across the country, began by studying white blood cells from hundreds of patients with severe burns, trauma or sepsis to see what genes were being used by white blood cells when responding to these danger signals.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The researchers found some interesting patterns and accumulated a large, rigorously collected data set that should help move the field forward, said Ronald W. Davis, a genomics expert at Stanford University and a lead author of the new paper. Some patterns seemed to predict who would survive and who would end up in intensive care, clinging to life and, often, dying.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The group had tried to publish its findings in several papers. One objection, Dr. Davis said, was that the researchers had not shown the same gene response had happened in mice.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"They were so used to doing mouse studies that they thought that was how you validate things," he said. "They are so ingrained in trying to cure mice that they forget we are trying to cure humans."</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"That started us thinking," he continued. "Is it the same in the mouse or not?"</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The group decided to look, expecting to find some similarities. But when the data were analyzed, there were none at all.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"We were kind of blown away," Dr. Davis said.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The drug failures became clear. For example, often in mice, a gene would be used, while in humans, the comparable gene would be suppressed. A drug that worked in mice by disabling that gene could make the response even more deadly in humans.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Even more surprising, Dr. Warren said, was that different conditions in mice — burns, trauma, sepsis — did not fit the same pattern. Each condition used different groups of genes. In humans, though, similar genes were used in all three conditions. That means, Dr. Warren said, that if researchers can find a drug that works for one of those conditions in people, it might work for all three.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The study's investigators tried for more than a year to publish their paper, which showed that there was no relationship between the genetic responses of mice and those of humans. They submitted it to the publications Science and Nature, hoping to reach a wide audience. It was rejected from both.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Science and Nature said it was their policy not to comment on the fate of a rejected paper, or whether it had even been submitted to them. But, Ginger Pinholster of Science said, the journal accepts only about 7 percent of the nearly 13,000 papers submitted each year, so it is not uncommon for a paper to make the rounds.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Still, Dr. Davis said, reviewers did not point out scientific errors. Instead, he said, "the most common response was, 'It has to be wrong. I don't know why it is wrong, but it has to be wrong.' "</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">The investigators turned to Proceedings of the National Academy of Sciences. As a member of the academy, Dr. Davis could suggest reviewers for his paper, and he proposed researchers who he thought would give the work a fair hearing. "If they don't like it, I want to know why," he said. They recommended publication, and the editorial board of the journal, which independently assesses papers, agreed.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Some researchers, reading the paper now, say they are as astonished as the researchers were when they saw the data.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"When I read the paper, I was stunned by just how bad the mouse data are," Dr. Fink said. "It's really amazing — no correlation at all. These data are so persuasive and so robust that I think funding agencies are going to take note." Until now, he said, "to get funding, you had to propose experiments using the mouse model."</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Yet there was always one major clue that mice might not really mimic humans in this regard: it is very hard to kill a mouse with a bacterial infection. Mice need a million times more bacteria in their blood than what would kill a person.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"Mice can eat garbage and food that is lying around and is rotten," Dr. Davis said. "Humans can't do that. We are too sensitive."</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">Researchers said that if they could figure out why mice were so resistant, they might be able to use that discovery to find something to make people resistant.</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin: 0px 0px 1em; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); ">"This is a very important paper," said Dr. Richard Hotchkiss, a sepsis researcher at Washington University who was not involved in the study. "It argues strongly — go to the patients. Get their cells. Get their tissues whenever you can. Get cells from airways."</p><p itemprop="articleBody" style="color: black; font-size: 1.2em; margin-top: 0px; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; line-height: 24px; font-family: Georgia, serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); position: static; z-index: auto; ">"To understand sepsis, you have to go to the patients," he said.</p></div><a href="http://www.nytimes.com/2013/02/12/science/testing-of-some-deadly-diseases-on-mice-mislead-report-says.html?pagewanted=print">http://www.nytimes.com/2013/02/12/science/testing-of-some-deadly-diseases-on-mice-mislead-report-says.html?pagewanted=print</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><br class="webkit-block-placeholder"></div>

Health Testing on Mice Is Found Misleading in Some Cases - NYTimes.com

For decades, mice have been the species of choice in the study of human diseases. But now, researchers report evidence that the mouse model has been totally misleading for at least three major killers — sepsis, burns and trauma. As a result, years an…

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Sr Service Inventory Manager (# 109115)

<div dir="ltr" style="text-align: left;" trbidi="on"><div class="WordSection1"><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Position:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Sr Service Inventory Manager<o:p></o:p></span></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Location:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Milpitas, CA<o:p></o:p></span></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Duration:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Full time<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Job Description:<o:p></o:p></span></b></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"><o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">The GSS Service Inventory Senior Manager is responsible for setting inventory goals, monitoring and forecasting all aspects related to global service inventory as well as driving a multi-disciplinary and matrixed organization to achieve inventory targets. This person will work closely with GSS finance, procurement, planning and product teams to set and control inventory levels, manage quarterly reserve setting, support internal and external audits, execute quarterly excess scrap and perform in-depth inventory analyses whose findings lead to improved inventory performance across the world.<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Preferred Qualifications:<o:p></o:p></span></b></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Education:  BS/BA Business or related field with preferred concentration in Operations or Supply Chain Management (MS/MBA preferred a plus).<o:p></o:p> </span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Experience: 5 years of experience in a high-tech supply chain environment. Specific Inventory Management or Finance experience preferred. The ideal candidate will have experience working with exec level staff members on operational and financial reviews.</span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10pt;">Skills: Must have excellent written and oral communications skills and be comfortable coordinating tasks across multiple functions.  Must be comfortable working at all levels in the organization from front-line staff to C-level executives. The candidate is required to be a strong team player with excellent analytical and problem solving skills and the ability to drive to results while maintaining excellent relationships.  Experience with MS-Access and other database management is essential. Programming skills would be a plus.<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Basic Qualifications:<o:p></o:p></span></b></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Bachelor's degree with at least 5 years of experience in complex manufacturing supply chain environment. <o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Kindly send your resume to <a href="mailto:raju.balaji@kla-tencor.com">raju.balaji@kla-tencor.com </a><o:p></o:p></span></div></div></div>

Sr Service Inventory Manager (# 109115)

Position: Sr Service Inventory ManagerLocation: Milpitas, CADuration: Full timeJob Description:The GSS Service Inventory Senior Manager is responsible for setting inventory goals, monitoring and forecasting all aspects related to global service inven…

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Import/Export Analyst with Trade Compliance (HTS | CCATS | ECCN code) (# 109097)

<div dir="ltr" style="text-align: left;" trbidi="on"><div class="WordSection1"><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Position:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Import/Export Analyst<o:p></o:p></span></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Location:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Milpitas, CA<o:p></o:p></span></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Duration:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"> Full time<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Job Description:</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;"><o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">The Global Import/Export Analyst responsibilities will cover all import and export activity across the global KLA-Tencor service network.  Responsibilities will include review of HTS classifications to assure legal and most favorable duty treatment in each import jurisdiction, support applications for binding rulings with customs authorities to reduce impacts to key products used in support of service customers, auditing of service organizations to assure they are compliant with all import and export regulations in their given region.  Support to regional logistics managers to overcome trade compliance issues in their regions.<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">The Import/Export Analyst will work closely with our global service logistics team as well as cross functional teams to drive program improvements through information analysis and process management. This individual will be responsible for evaluating opportunities to establish bonded operations in key regions where KLA-Tencor will see significant financial returns.<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">The Import/Export Analyst will be responsible for driving lowest possible compliance costs across the KLA-Tencor Service supply chain while assuring legal compliance with customs laws in each country where we act as importer or exporter of record.<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">This job will require regular international travel to Asia and Europe to review import and export compliance.<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Preferred Qualifications</span></b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">:<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">1) B.S. or B.A. degree in finance, intentional business or supply chain<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">2) Minimum of 5 years experience in global trade and compliance organization with large US based Experience commodity code classifications in US, Asia and Europe. Most specifically China, Taiwan, Korea and EU<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">3) Strong understanding of bonded warehouse transfers in China<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">4) Understanding of service supply chain and high technology parts a plus<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><b><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Basic Qualifications:<o:p></o:p></span></b></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Bachelor's Level Degree in finance, intentional business or supply chain.<o:p></o:p></span></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">At least 5 year experience in global trade and compliance organization with large US based corporation.<o:p></o:p></span></div><div class="MsoNormal"><br /></div><div class="MsoNormal"><span style="font-family: "Arial","sans-serif"; font-size: 10.0pt;">Kindly send your resume to <a href="mailto:raju.balaji@kla-tencor.com">raju.balaji@kla-tencor.com</a><o:p></o:p></span></div></div></div>

Import/Export Analyst with Trade Compliance (HTS | CCATS | ECCN code) (# 109097)

Position: Import/Export AnalystLocation: Milpitas, CADuration: Full timeJob Description:The Global Import/Export Analyst responsibilities will cover all import and export activity across the global KLA-Tencor service network.  Responsibilities will i…

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How many pancakes did you eat?!

<p>Today is the last day before Lent.  Here in Ireland we call this Shrove Tuesday or Pancake Tuesday.  Traditionally we eat pancakes today and then make a decision to forgo something nice for Lent which leads us up to Easter.  </p><p>By the way, I had 1 pancake today.  How many did you have?!</p><div class='separator' style='clear: both; text-align: center;'> <a href='https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWcOhbtW2LOWn5YBtumC86wubheqbVaPF0uwG1H-DG08K5vXNdLCV95YIsRYfoTuBKLCVeqQ6v193T-a9MINVtyQWusBuFFvAOWrWsMvFGPdmjmSkyNrafYkKWj3Bn9fA3PdhvXoX7aVvv/s1600/2013-02-12-22-27-59--340948423.jpeg' imageanchor='1' style='margin-left: 1em; margin-right: 1em;'> <img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWcOhbtW2LOWn5YBtumC86wubheqbVaPF0uwG1H-DG08K5vXNdLCV95YIsRYfoTuBKLCVeqQ6v193T-a9MINVtyQWusBuFFvAOWrWsMvFGPdmjmSkyNrafYkKWj3Bn9fA3PdhvXoX7aVvv/s400/2013-02-12-22-27-59--340948423.jpeg" /> </a> </div>

How many pancakes did you eat?!

Today is the last day before Lent.  Here in Ireland we call this Shrove Tuesday or Pancake Tuesday.  Traditionally we eat pancakes today and then make a decision to forgo something nice for Lent which leads us up to Easter.  By the way, I had 1 panca…

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28 in 28 #12: Cycle Space

<i>February is Book Month on A Daily Dose of Architecture. The "<a href="http://archidose.blogspot.com/search/label/28%20in%2028">28 in 28</a>" series features a different book every day of the month.</i><br /><br /><a href="http://www.010.nl/catalogue/book.php?id=812"><b><i>Cycle Space: Architectural and Urban Design in the Age of the Bicycle</i></b></a> by Steven Fleming<br />nai010 Publishers, 2012<br />Paperback, 176 pages<br /><br /><img alt="28-28_cycle.jpg" src="http://www.archidose.org/Blog/28-28_cycle.jpg" title="Book cover" /><br /><br />On page 20 of <i>Cycle Space</i> <a href="http://cycle-space.com/">Steven Fleming</a> admits, "By reading this book, you're indulging my bike-centric worldview that says walking is tiresome and boring." It's funny to think that a book promoting bikes in cities would find an issue with walking, rather than setting its sights squarely on the automobile (which it does at times), but this rather humorous comment starts to get at the gist of Fleming's book: The qualities that make biking a desirable thing need to be recognized in order to be considered spatially in an appropriate manner. Fleming discusses the usual reasons to opt for a bike over a car, or even walking—cutting carbon emissions, getting in shape, reducing traffic—but he prioritizes the sheer pleasure of riding a bike over any of these.<br /><blockquote><i>Our shame as architects and urban designers is that we have sat back and allowed by-the-book engineers to design infrastructure for bikes with even less inspiration and care than they would apply when designing a road. It's time someone intervened.</i></blockquote>This next quote comes much later in the book, but at this point the link between the pleasures of cycling and the space that bike's occupy is clear. More considered streets and other thoroughfares that take the act of bike riding into account—rather than just setting aside a strip based on the "real estate" a bike and rider occupies—should be the goal. Fleming's argument unfolds across 8 cities around the globe, accompanied by 8 chapters on related considerations: New York and "From Cars to Bikes," Copenhagen and "Aesthetics, Modernism and Meaning," Portland and "If Architects Designed Bicycle Transit" (from where the above quote is taken), and so forth. The tours are cursory and funny at times, but they do a great job of honing in on what is unique about each context, such as the historical importance in Portland's decision to let a highway bypass the city, creating bike thoroughfares and nurturing the potential for bicycling in a rainy and hilly place.<br /><br />Focusing on pleasure has other consequences that accompany reshaping city spaces for bikes, such as provisions for bike commuting. I was a warm-weather bike commuter when I lived in Chicago, using the busy but lovely lakeshore bike path, but getting to work drenched with sweat kept me from doing the 15-mile round-trip ride more often; and the perceived danger in riding a bike in New York City (confirmed on my first few attempts) has kept me off my two wheels here for a while. Yet when employees add showers, and cars and pedestrians respect bikes in a mutual sharing of the street (an ideal that may be a pipe dream) then the pleasures of riding extend to commuting, not just weekend rides. Ultimately I find Fleming's argument appealing for the United States, where the automobile is still seen as an enjoyable way of getting around, even as increasingly long and stressful commutes are tempering this long held notion. Reorienting that stance to include bicycling might just have the effect of balancing the different modes of transit on our city streets. In this regard Fleming has given readers and bikers 8 snapshots and many more ideas for thinking about ways to move forward.<br /><br /><b>US: <a href="http://www.amazon.com/gp/product/9462080046/ref=as_li_tf_il?ie=UTF8&camp=211189&creative=373489&creativeASIN=9462080046&link_code=as3&tag=aweeklydoseof-20" target="_blank"><img alt="Buy from Amazon.com" border="0" src="http://www.archidose.org/books/buy-from-tan.gif" /></a> CA: <a href="http://www.amazon.ca/gp/product/9462080046/ref=as_li_tf_il?ie=UTF8&camp=211189&creative=373489&creativeASIN=9462080046&link_code=as3&tag=aweeklydoseof-20" target="_blank"><img alt="Buy from Amazon.ca" border="0" height="28" src="http://www.archidose.org/books/buy-from-tan-ca.gif" width="90" /></a> UK: <a href="http://www.amazon.co.uk/gp/product/9462080046/ref=as_li_tf_il?ie=UTF8&camp=211189&creative=373489&creativeASIN=9462080046&link_code=as3&tag=aweeklydoseof-20" target="_blank"><img alt="Buy from Amazon.co.uk" border="0" height="28" src="http://www.archidose.org/books/buy-from-tan-uk.gif" width="90" /></a></b>

28 in 28 #12: Cycle Space

February is Book Month on A Daily Dose of Architecture. The "28 in 28" series features a different book every day of the month.Cycle Space: Architectural and Urban Design in the Age of the Bicycle by Steven Flemingnai010 Publishers, 2012Paperback, 17…

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Today's archidose #649

Here are some photos of the Zug Schleife Apartments (2012) in Zug, Switzerland, by <a href="http://www.olgiati.net/">Valerio Olgiati</a>, photographed by <a href="http://www.flickr.com/photos/heckhausen/">van der Heckhuizen</a>.<br /><br /><a href="http://www.flickr.com/photos/heckhausen/8454724500/" title="Zugschleife by van der Heckhuizen, on Flickr"><img alt="Zugschleife" height="427" src="http://farm9.staticflickr.com/8530/8454724500_039508415b_z.jpg" width="640" /></a><br /><br /><a href="http://www.flickr.com/photos/heckhausen/8454722290/" title="Zugschleife by van der Heckhuizen, on Flickr"><img alt="Zugschleife" height="544" src="http://farm9.staticflickr.com/8241/8454722290_bba332f246_z.jpg" width="640" /></a><br /><br /><a href="http://www.flickr.com/photos/heckhausen/8453630949/" title="Zugschleife by van der Heckhuizen, on Flickr"><img alt="Zugschleife" height="800" src="http://farm9.staticflickr.com/8507/8453630949_550c12957d_c.jpg" width="534" /></a><br /><br /><a href="http://www.flickr.com/photos/heckhausen/8453631451/" title="Zugschleife by van der Heckhuizen, on Flickr"><img alt="Zugschleife" height="800" src="http://farm9.staticflickr.com/8229/8453631451_0c9f313616_c.jpg" width="534" /></a><br /><br /><a href="http://www.flickr.com/photos/heckhausen/8453630315/" title="Zugschleife by van der Heckhuizen, on Flickr"><img alt="Zugschleife" height="800" src="http://farm9.staticflickr.com/8522/8453630315_b5f8421de4_c.jpg" width="522" /></a><br /><br />To contribute your Flickr images for consideration, just:<br /><blockquote>:: Join and add photos to the <a href="http://www.flickr.com/groups/archi-dose/">archidose pool</a>, and/or<br />:: Tag your photos <span style="font-style: italic;"><a href="http://www.flickr.com/photos/tags/archidose/">archidose</a></span></blockquote>

Today's archidose #649

Here are some photos of the Zug Schleife Apartments (2012) in Zug, Switzerland, by Valerio Olgiati, photographed by van der Heckhuizen.To contribute your Flickr images for consideration, just::: Join and add photos to the archidose pool, and/or:: Tag…

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Part Time Children's Librarian - Guilford Smith Memorial Library, South Windham

<b>Part Time Children's Librarian - </b><b><span style="color: #48286d;">Guilford Smith Memorial Library</span></b>, South Windham. Applicants must have experience working with children and computer skills. No library experience is necessary. Education students are encouraged to apply. Prior experience working in childcare, child development, pre-school or Elementary Education is desirable. This position is 10 hours a week. Hours are Tuesdays 1-8PM and Thursdays 5-8PM with one rotating Saturday a month from 10AM - 2PM. The successful candidate is organized, creative, enthusiastic, and able to work well with others. Must be a self-starter and have a positive attitude. To apply for the job please email a cover letter and resume to the Library Director, Afton Seal at <a _fcksavedurl="mailto:aseal@biblio.org" href="mailto:aseal@biblio.org">aseal@biblio.org</a>.

Part Time Children's Librarian - Guilford Smith Memorial Library, South Windham

Part Time Children's Librarian - Guilford Smith Memorial Library, South Windham. Applicants must have experience working with children and computer skills. No library experience is necessary. Education students are encouraged to apply. Prior expe…

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Library Assistant - Jonathan Trumbull Library, Lebanon

<strong>Library Assistant - </strong><strong><span style="color: #48286d;">Jonathan Trumbull Library</span></strong>, Lebanon. Knowledgeable, energetic, tech-savvy, friendly, self-starter to work in our busy children’s library and to perform other duties as assigned. Strong organizational skills, attention to accuracy, customer service skills and a positive attitude are essential. The successful candidate will have excellent interpersonal, written and verbal communication skills, knowledge of children’s literature, and proficiency in Microsoft Word and MS Office software. High school diploma required; college and previous library experience preferred. 18.5 hours per week, Mondays, Wednesdays, and every other Saturday. $11.96 per hour, no benefits. Send resume, cover letter and 3 professional references to Director, Jonathan Trumbull Library, P.O. Box 145, Lebanon, CT 06249.

Library Assistant - Jonathan Trumbull Library, Lebanon

Library Assistant - Jonathan Trumbull Library, Lebanon. Knowledgeable, energetic, tech-savvy, friendly, self-starter to work in our busy children’s library and to perform other duties as assigned. Strong organizational skills, attention to accur…

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