News for today's 2018

Can a Radical New Treatment Save Children With Severe Food Allergies? - NYTimes.com

2:17 PM Tukiyooo 0

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; ">For nine years, the greatest challenge Kim Yates Grosso faced each day was keeping her daughter Tessa safe. Tessa was so severely allergic to milk, wheat, eggs, nuts, shellfish and assorted other foods that as a toddler she went into <a href="http://health.nytimes.com/health/guides/disease/anaphylaxis/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Anaphylaxis." class="meta-classifier" style="color: rgb(102, 102, 153); text-decoration: none; ">anaphylactic shock</a> when milk fell on her skin. Kim never left her with a baby sitter. She slept with her each night. And when she needed to work, she found a job she could do primarily from home in the evenings. She successfully lobbied the Menlo Park, Calif., school district to provide Tessa with a full-time aide (in accordance with the Americans With Disabilities Act) to shadow her at all times. She made all of Tessa's food from scratch, including safe treats to bring to birthday parties, when she could persuade her daughter to attend them at all. Tessa never spent the night at a friend's house — she didn't feel comfortable sleeping in an unsafe environment.Originally Kim insisted the whole family eat only the foods Tessa could, but then she realized it wasn't fair for her younger daughters not to be able to eat like other kids at school and birthday parties. Suppose you couldn't walk, Kim said, explaining her thinking to Tessa; should I make your sisters sit in wheelchairs too? Kim herself kept to Tessa's diet, however — Tessa never saw her mother so much as add milk to her tea.Yet this carefully constructed world was in constant danger of collapse. In 2011, Tessa almost died twice. First, when she was 7, a piece of rye toast turned out to contain traces of wheat. Then, 10 months later, Kim took a small uncharacteristic break from their rigid food routine and bought some Vietnamese summer rolls from a restaurant after quizzing the staff about each of the ingredients. But the clear noodles that she was told were rice turned out to be made of wheat, and soon Tessa was losing consciousness. She didn't have hives or other external signs parents often rely upon, but internally her body shut down. At her doctor's office, the medical team had to use two EpiPens, adrenaline-loaded syringes, along with steroids and an array of drugs to bring her back. (Injected adrenaline is the only known antidote with the power to arrest anaphylactic shock, the allergic-immune response that causes tissues throughout the body to swell until the windpipe closes, the lungs collapse and the heart fails.)A week later Tessa began having panic attacks. She no longer wanted to leave the house without her mother — even to go to school or diving practice. She was afraid to eat. "Her belief was, If I don't eat, I can't die," Kim recalled in one of our many conversations over the last year. When Kim went away for the weekend, she returned to discover her daughter had eaten only one bowl of plain white rice in 48 hours. At school Tessa didn't want to touch anybody or anything. What if at recess the kickball had rolled through a splash of milk or some bread crumbs in the courtyard where kids ate their lunches? Costly sessions with a child psychiatrist were of limited value. Treatment for obsessive-compulsive disorders like germ phobia teaches the sufferer to distinguish anxiety from reality, but the reality for a severely allergic child is that invisible trace contaminants can kill.Kim, a pretty 42-year-old with wholesome girl-next-door looks, has a particular optimistic energy indigenous to Silicon Valley: an entrepreneurial drive, buoyed by a sunny, hopeful Northern California temperament, embedded in a community of people who make dreams — at least of a certain sort — come true. Although she and her husband, Andy, an executive recruiter, were not in a position to write big checks, Kim had been involved in enough philanthropic efforts to know she could mobilize tremendous resources. She grew up in the area and was the kind of person who couldn't walk into a coffee shop without people coming over to thank her for her help with some enterprise or to try to enlist her for another.Kim realized that her daughter was born on the cusp of an epidemic. When milk first splashed on Tessa's skin, Kim was thrust into a strange, lonely world, where few parents shared or understood her anxieties. In the following years, however, she watched food <a href="http://health.nytimes.com/health/guides/disease/allergies/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Allergies." class="meta-classifier" style="color: rgb(102, 102, 153); text-decoration: none; ">allergies</a> explode into a major public-health problem. The <a href="http://www.cdc.gov/nchs/data/databriefs/db10.htm#howdoes" style="color: rgb(102, 102, 153); text-decoration: none; ">rate of food allergies</a> has more than doubled over the past decade, and there are now an estimated 5.9 million children in the United States with food allergies (along with another 2.3 million adults); to put it another way, in every classroom, roughly 1 in 13 children will have a food allergy. That number may rise in the future, as food allergies are now even more prevalent in children between 3 and 5 years old — nearly 1 in 10 preschoolers — and it seems as if children aren't growing out of their allergies at the rate they did before. In our children's (nut-free) nursery school, their EpiPen packs are on a shelf with five others — the first time their teacher has seen that many in her long career.In April 2009, Kim heard that Kari Nadeau, an M.D./Ph.D. and an associate professor of allergies and immunology at Stanford University School of Medicine and Lucile Packard Children's Hospital, was giving a lecture at Stanford. Kim had recently flown across the country to meet an expert in New York to see if anything could be done for her daughter. He wasted no time in telling her, "We're not hiding the answer under a rock here," and advised her simply to continue their regimen of strict avoidance. While young children frequently outgrow allergies, Tessa's case offered little hope, because her blood work showed high quantities of an immune protein called IgE, which is used as a marker of the severity of the allergic response.Nadeau and others, however, were having success with a trial of a treatment known as oral immunotherapy that could desensitize children with severe peanut allergies. The treatment re-educated the hyperactive immune systems of allergy patients by giving them minute doses of peanut every day, gradually escalating the amount over the course of several years. Eventually patients build up their tolerance for the food, and it is no longer dangerous.Desensitization is a straightforward idea; it's the same principle, according to legend, that King Mithridates VI used to cultivate immunity to poison (an occupational hazard of royalty in the ancient world). The therapy has been used successfully for environmental allergies for decades, by giving patients small injections of pollen or cat dander or other allergens, but it was considered too dangerous to try with food allergies until recently. A study testing various allergens was pioneered in Europe in the 1980s, and in the past five years, ongoing studies at Mount Sinai School of Medicine in New York and other centers have shown that children can be safely desensitized to a single allergen, peanut, and, in separate trials, to milk and egg.But Tessa was allergic to more than a dozen foods. If she were to enroll in single-allergen trials, simply being desensitized of three of her allergens would take the better part of a decade.People hearing Nadeau talk for the first time often describe falling under her spell. As Nadeau lectured, Kim became filled with conviction: This is the person who will cure my daughter. Afterward she approached Nadeau and asked what she could do for her 6-year-old, who was fatally allergic to most major food groups."I am not sure," Nadeau told her, "but I promise, we will figure it out."Kim's question intrigued Nadeau. Could patients be desensitized to more than one allergen at a time? No one had ever tried it, but more than a third of children with food allergies are allergic to more than one food. If it was safe to give patients x milligrams of one allergen, would it be safe to give them one-fifth of x milligrams of five different allergens, as long as the total dose remained the same? That would assume that allergens function in a linear, additive fashion — rather than a multiplicative one; it was also possible that they could interact with one another to produce a more severe reaction.Nadeau experimented with blood samples of allergic patients and was encouraged to see that the allergens seemed not to interact with one another. She consulted with senior colleagues in the field to see if anyone would collaborate on a multiallergen study, but no one was interested. Scientifically the results would be harder to interpret than single-allergen trials. Moreover, each allergen would require getting separate F.D.A. approval, and it was difficult to get even one application approved. When she found herself home sick in bed with a virus for a few days in 2011, she decided she would "knock them all out" and wrote 13 Investigational New Drug Applications, each 90 or so pages long, and soon received F.D.A. approval for each one.Even more daunting was the question of how to finance the study. Each child would cost between $20,000 and $30,000 to treat annually, and treatment could take several years. Flour would have to be manufactured from the proteins of each allergen to prepare precisely measured, minute doses, and it would have to meet the high purity standard for drugs. While there were more than enough parents in the area who could afford this treatment, ethical rules governing trials prohibit individuals from "buying" places by paying for themselves.Nadeau applied for research grants, but none materialized. While food allergies cost an estimated $500 million a year, Congress recently appropriated only $28 million a year for research (compared with, say, $1 billion for diabetes and $5 billion for cancer). The <a href="http://www.foodallergy.org/" style="color: rgb(102, 102, 153); text-decoration: none; ">Food Allergy Research and Education group (FARE)</a>, the only major food-allergy organization, spent an additional $3.4 million for research last year. Nadeau believed she had an important idea — one that could revolutionize her patients' lives — but in a situation that young researchers often face, she couldn't compete for grants without proving her idea, and she couldn't do that without financing.The only alternative seemed to be raising money directly from private individuals. No one had heard of this kind of major trial being financed through grass-roots philanthropy, but Nadeau often reminded herself of Margaret Mead's words: "Never doubt that a small group of thoughtful, committed citizens can change the world." She and Kim began to talk about how to do it, and Kim organized a group of mothers of children with severe allergies to work with Nadeau's <a href="http://foodallergies.stanford.edu/" style="color: rgb(102, 102, 153); text-decoration: none; ">Stanford Alliance for Food Allergy Research</a>. The women, who call their group the Safar Community Council, immediately bonded: no one understood the lives they all were living better than they did. The group had an abundance of passion, skill and advanced degrees to draw upon: many of the women had forsaken careers to care for their allergic children.The council members reached into their own pockets again and again and implored family and friends. When the financing fell short, two sets of Safar parents who had already made initial donations, Melissa and Scott Kepner and Shirley Chu Orsak and Mike Orsak, agreed to split the balance. To keep giving, the Kepners canceled several family vacations: when they thought about whether they really wanted to go skiing for Thanksgiving or give more to the multiallergen study, they voted for the study. (Traveling with their young daughter Kate, who was severely allergic to eggs, milk and nuts, was no small feat. The first thing Melissa did at hotels was ask to use a vacuum, to ensure their toddler wouldn't find a peanut under the sofa — perhaps a first for the Four Seasons. Then they set up camp with their own toaster, hot plate and food rather than risk a restaurant.) Steve Carell volunteered to host a fund-raising auction, because Nadeau treated his daughter, Annie, for a dairy allergy in an earlier study.Nadeau herself decided to forgo a salary for three years. She was left with only a small salary from clinical care, which — considering the high cost of child care — left her with negative cash flow. "My husband was a bit cross," she told me, laughing.By November 2011, the Safar Council had raised enough money for two multiallergy trials with 85 patients, each of whom could be desensitized to up to five allergens. (To date, the group has raised $6.2 million, including recent grants from FARE and the National Institutes of Health — $2.2 million to finance the multiallergen trial and $4 million to establish an endowment for food-allergy research.)Food allergies are a peculiar disease, because most of the time the child is not sick — indeed, she may be bursting with health — but is in omnipresent danger. Statistically the chance of dying is slight. Although the number of emergency-room visits for anaphylaxis caused by food has gone up significantly in the past decade — to as many as 90,000 in a year — only 100 to 200 people die (although statistics are difficult to collect because such deaths are often coded as cardiac arrest). Even for a severely allergic child like Tessa, the mortality rate is estimated at roughly 1 in 1,000, because parents of such children tend to be extremely careful. But food allergies amplify a kind of fear every parent experiences — of a child dashing suddenly into the street and, just like that, being gone. Your child is always playing near a precipice that is visible only to you: you may be able to keep her from falling off, but you can never move her away from the edge.At Safar Council meetings (which I joined last fall), parents would look around the room and ask themselves if their story would be like Shirley Chu Orsak's, whose daughter, Nicole, felt her throat close up one day in fifth grade. Her mother always told her, "No one knows your body better than you," so she ignored the adults urging her to wait for paramedics, got the EpiPen from her backpack, injected herself and saved her own life. Or would their story be like that of Brian Hom's, whose youngest son, Steven, is in the trial now in the wake of the death of his older brother, B.J., who ate a dessert that turned out to contain peanut while on a family trip to Mexico to celebrate his high-school graduation? The family didn't have an EpiPen, because they thought the worst that could happen was that he would get some itchy hives, as he had before. They still thought he would be O.K. when the medical team arrived, but then the doctor said, "I'm sorry," and pulled a blanket over his head and everything was over.Food allergies are nonsensical. "Why would evolution have us be allergic to the things that sustain us?" Nadeau asks. "What would Darwin say?"In an allergic reaction, an ordinary food protein like peanut is misidentified as an invader, like a virus or bacterium, to which the body needs to mount a defense. In the body of a person with a peanut allergy, for example, the presence of peanut protein causes the release of peanut-specific IgE antibodies, which sets off the release of a flood of chemicals, including histamines, into the bloodstream. Those chemicals lead to the release of still more chemicals, and the chemical cascade escalates in a self-sustaining feedback loop until the response causes the heart or the lungs to fail, and the person collapses — a victim of friendly fire in a battle with an imaginary enemy. An EpiPen will prevent death if it's used within 20 minutes of exposure, but after that window, the reaction cannot always be halted.Until recently, one common explanation for the rise of food allergies was the so-called hygiene hypothesis — the idea that the modern obsession with sanitation prevents children from being exposed to the bacteria and the parasites that enable the immune system to develop. With the immune system underemployed, so to speak, it begins to attack harmless targets. This hypothesis, however, has fallen out of favor; among other things, it turns out that allergies are rising worldwide, from Rio de Janeiro to Shanghai, in Europe and Britain, across environments that have a range of sanitary conditions. Moreover, children who grow up on farms with exposure to dirt and parasites and animals do not appear to have lower rates of food allergies (although they do have lower rates of environmental allergies, like hay fever or reactions to animals).Having a parent or a sibling with allergies (food or environmental) increases the risk that a child will have food allergies. One study of identical twins has led researchers to believe that food allergies are about 70 percent genetic in origin and 30 percent environmental.If allergies are primarily genetic, though, how could their incidence have risen so quickly? The traditional model of genetic change involves natural selection operating through a slow process of mutation, generation by generation, that, furthermore, results in traits that increase survival — not cause sudden death.Epidemiologically, food allergies parallel the steep rise of other contemporary epidemics like asthma, diabetes and autoimmune diseases — a phenomenon for which there has been no convincing explanation. Emerging evidence suggests that food allergies, however, fall in the province of the new field of epigenetics: the science of how the environment can alter the genetic inheritance one generation passes on to the next. One focus of Nadeau's lab is studying whether the toxins found in pollution, pesticides or tobacco smoke damage the genes in ways that make children more likely to have allergies and the intimately related disease of asthma. There is evidence that having a parent or a grandparent who smoked — even if the child was never exposed to smoke — is a risk factor for food allergies, as is living in an urban area with elevated pollution.Another focus of Nadeau's research is diet. "I see immigrants who come here from a country with a traditional diet, and then they adopt a Western diet, and their children have food allergies," she says. "We have to wonder: Is it the change in their diet or something else?"Important evidence that diet during pregnancy and early childhood affects food allergies has emerged from Europe. A recent study found that eating hydrogenated oils found in fast food during pregnancy is <a href="http://thorax.bmj.com/content/early/2013/01/03/thoraxjnl-2012-202285" style="color: rgb(102, 102, 153); text-decoration: none; ">associated with an increase in allergies and asthma</a>. Another study suggested that eating a Mediterranean diet during pregnancy (fruits, vegetables, olive oil, yogurt, fish and so forth), high in vitamin D and calcium, is <a href="http://www.ncbi.nlm.nih.gov/pubmed/18198206" style="color: rgb(102, 102, 153); text-decoration: none; ">associated with a decrease</a>. And according to a <a href="http://download.journals.elsevierhealth.com/pdfs/journals/0091-6749/PIIS009167491201696X.pdf" style="color: rgb(102, 102, 153); text-decoration: none; ">newly published study</a>, introducing rice and corn at 6 months, like Gerber's rice cereal — "Baby's first food" — increases the risk of food allergies, while introducing wheat before 6 months and eggs and fish before 9 months results in a decreased risk for asthma and allergies.Nadeau herself is aligned with the school of thought that speculates that the cause of food allergies could be "some element of interaction between genes and the environment — air pollution, tobacco smoke, chemicals in water or the food you eat. We are ingesting the proteins that are causing the allergies in a very different form and immune environment than when primitive man did."As a child living on a houseboat off the Jersey Shore, Nadeau suffered from severe asthma. She recalls the horrible feeling of lying awake at night laboring to breathe, without understanding how the damp moldy environment contributed. Her mother talked fondly about having been a cheerleader, but Nadeau's interests ran to science, and her desires focused on service. In college and medical school, she worked to bring medical care to disadvantaged people, from treating torture victims in Haiti to documenting tuberculosis in children in immigration detention centers in Texas.After receiving an M.D./Ph.D. from Harvard, she did a pediatrics residency, specializing in oncology-hematology. Most oncologists cope with their patients' suffering by detaching, but she couldn't, and she found the destructiveness of chemotherapy — the stark pain brought on by the treatment itself — too hard to bear. Because her dissertation focused on the immune system, she decided to switch to allergies and immunology. In between fellowships, she went to work in biotechnology and led the successful development of a new drug for non-Hodgkin's lymphoma. But she found working in the corporate world alienating and decided to return to research and caring for patients.She and her husband, Paul, a neurosurgeon with a Ph.D., decided that, although they loved children, given the demands of their research, they should content themselves with a small family and a lot of pets. They had a son, Christopher, and a menagerie, but then Nadeau became pregnant with twin girls, Jennifer and Stephanie. She and Paul both took positions at Stanford, and they bought a fix-up ranch house in Los Altos Hills and spent weekends at Home Depot.In 2004, when she was 38, Nadeau found out she had a rare cancer — cancer of the T-cell — for which there were no effective therapies. (T-cells play a critical role in the immune system and, coincidentally, the T-cell dysfunction that leads to food allergies was already a focus of her research.) Life expectancy was only a couple of years. "I went home and cried, and then I watched 'The Sound of Music' with my kids," she told me, "and that was the last time I cried." Although she said she doesn't believe you can pray illness away, she drew strength from her faith and the community of her church.In a small subset of patients, however, the cancer cells are actually caused by a virus, and over time it became clear she was in that lucky group — instead of multiplying, her cancer cells disappeared."I carry that experience with me," she said of having cancer. "Now I know how patients feel when they get these diagnoses." Soon thereafter, she found herself unexpectedly pregnant with her second set of twins, Katherine and Elizabeth. She became even more focused. "Every moment is managed," she said, from the half-hour she spends on the elliptical machine (while reading e-mail on her iPhone) to the spreadsheet on which all five children check off that they have completed their daily piano practice. She takes the children to scientific conferences when she travels, and she and her eldest three spent their last summer vacation on a trip to rural Mexico building houses.I met Nadeau a year and a half ago, after moving to Palo Alto, when we consulted with her about our son, Kieran, who was nearly 2. When Kieran was 5 months old, my husband and I noticed that 20 minutes after he drank breast milk, a red rash appeared around his mouth. The same thing happened with cow- and soy-milk formula, so we took him to an allergy doctor, who recommended hemp milk, a watery substance extracted from the hemp plant. When he started solid food (beginning with rice cereal), she suggested we try cheese, as the milk proteins in cheese are different from those in raw milk.Early one evening, I gave him a nibble of Havarti — which I chose because it somehow struck me as particularly innocent. Immediately he began to fuss and rub his eyes. I stepped into the bathroom to get him some eye drops; when I returned a few seconds later, I almost didn't recognize him. It was like a moment in a fairy tale when a child is transformed into a beast: his face was swollen and covered with scaly red splotches, and his eyes looked small and sunken. We ripped off his clothes and saw that horrible scales were spreading down his torso. He began to wheeze and gasp for breath. We threw him in the car and drove to the hospital, a few minutes away."Next time," the E.R. doctor told us, "just call 9-1-1."Next time? I thought, staring at him with horror. What kind of parents do you think we are? There will never be a next time. But there was: a next time and a time after that and a time after that. By the time he was 3, he had to be revived with an EpiPen three times. He turned out to be allergic to legumes as well as to dairy and soy, and to the egg in the dairy-free apple cake at his first birthday, so that the party ended with a hospital stay. Six months later, he got hold of a cookie that contained eggs and nuts. I saw him pop it in his mouth, and I grabbed it before he bit down and dragged him to the sink to wash his mouth out. I thought I caught it in time, but we decided to drive to the hospital and sit in the parking lot to be safe. In the car, red hives began to speckle his face, and his lips turned blue. I didn't know then that blue lips are a sign of oxygen deprivation, but I understood something terrible was happening. I took the EpiPen and plunged it into his thigh.By the time he was 2, he outgrew his allergies to dairy, soy and legumes but not to eggs or nuts or sunflower seeds, and like Persephone's pomegranate seeds, they have brought him to the mouth of Hades, again and again. Each night, I would wake to check him in his crib. I would touch his face until, bothered, he would sigh or flop over, and I would know he was only sleeping. Sometimes I'd wake from a nightmare in which all of our EpiPens had disappeared and he was gasping for breath again, his eyes round with terror. I would open the drawer to my night table, where I keep an extra EpiPen for reassurance, and close my fingers around it. One in a thousand. During the day, the mortality rate seemed slight, but at night it loomed large.Kieran began treatment last March, the way all the children in the trials begin, by verifying his allergies through a "food challenge," in which just enough of the food is given to provoke a small reaction. His first challenge was to cashew — a nut we had been told he was allergic to based on blood work but which he had never actually eaten. I knew that Nadeau had done more than a thousand food challenges and rarely had to use an EpiPen, but I still felt sick with dread. He began at one milligram (1/360 of a cashew) and then, an hour later, a larger dose. After a few more doses, I was beginning to wonder if he actually had a cashew allergy. Then he began to cry and flail his arms, as if he had been dropped overboard and was trying to keep from drowning. One by one over the next 20 minutes, the maximum doses of different medications failed to halt the hideous metamorphosis, and they had to use the EpiPen.Forget this, I thought. My son is not going to be the canary in the coal mine.Kieran fell asleep in his car seat on the way home, and he woke up happy as always, chattering about a squishy purple rubber toy that Tina, the physician assistant at the clinic, gave him. By the time we were home, my own feelings had changed; I realized that the severity of his reaction only underscored the need for the treatment.For some children, food allergies are part of what is known in medical literature as the atopic march: a classic progression of immunological problems, from having eczema as a baby to developing food allergies between 1 and 3 years and then asthma between 4 and 6. Asthma and allergies are a dangerous combination, because allergic attacks initiate respiratory distress that sets off asthma; having both conditions greatly increases the risk of dying during anaphylaxis. Because both are believed to be part of a common pathology, one important research question Nadeau is trying to answer is whether treating food allergies early in a child's life could prevent the child from developing asthma. Food allergies also impair growth: children with food allergies have a lower body mass index than children without, and those with more than two allergies are shorter as well.Justine (who asked that I not use her last name in order to protect her family's privacy) has a son who experienced just this sort of frightening trajectory. When Jack was 8 weeks old, Justine decided to stop breast-feeding so she could go back to work at the nonprofit she founded, and "all hell broke lose," she recalled. Jack developed severe eczema, consumed very little formula, cried inconsolably when they tried to feed him and rapidly lost weight.She took him to countless specialists from the time he was an infant, but it was not until 2009, when Jack was 4, that Justine found her way to Nadeau, who diagnosed severe allergies to nuts, citrus, watermelon, garlic, onion, cucumbers and many other foods. By the time he was 6, he outgrew all his food allergies except cashews and pistachios. But his asthma was very severe; for unknown reasons (perhaps because the asthma made the act of breathing itself burn too many calories), he stopped growing when he was 5, and by the time he was 7, he had dropped to the 20th percentile in height from the 70th, while his weight fell to below the first percentile. He also suffered from severe reflux and, perhaps because of that, was often nauseated and reluctant to eat.Although Justine was a founder of the Safar Council, she was scared to allow her own little boy to participate in the multiallergen trial, because she felt that the science was too new and feared destabilizing his precarious health. Then one day in first grade, Jack was eating a sandwich Justine prepared with whole-wheat bread, and he suffered a severe allergic attack. When Nadeau analyzed the bread in the lab, it turned out to contain traces of cashew. (The company subsequently added a label stating that the bread was made on shared equipment with cashew. Labeling in the United States permits companies not to list so-called trace contaminants, which are defined as up to roughly 200 milligrams, or about a whole peanut — more than enough to cause anaphylaxis in some people.) It was clear to Justine that there was no way to protect Jack — any time he ate a bite of anything, his life was at risk."I suddenly realized the trial was the opportunity of a lifetime," she said. "We couldn't afford to wait any longer."For Tessa, not eating dairy, wheat, egg, peanut and almond had been the inviolable commandment of her life. Now she was being asked to forget all that. Her starting dose, in January 2012, when she was 9, was one milligram each of flour made from the proteins of her allergens — a dose so small it looked like a few shavings of nutmeg. Over the course of treatment, she would increase the amount to 4,000 to 6,000 milligrams of each food — the equivalent of about 2 pieces of toast, 1 egg, 1 cup of milk, 16 peanuts and 16 almonds.She and her parents had to commit to a rigid regimen of taking the dose every day at roughly the same time. Each afternoon, Tessa would have to hurry home from diving or soccer practice to eat dinner so she could take her dose on a full stomach two hours before bed. Her parents would then anxiously monitor her for two hours, while she did homework, avoiding exertion, hot showers or anything else that would make her body temperature rise, which can facilitate anaphylaxis. If she reacted to a dose at home the night before (or if she was sick), she could take a half-dose the next day, but she could never skip a day.Every two weeks, she would visit the hospital for what is known as an updose.On those days, Tessa would dawdle while her family filled the small hospital room, eyeing her anxiously as she finally swallowed her dose mixed with applesauce, then waiting to see if her body would accept the increased amount. Spirited and sassy, Tessa could go from dancing around the room before the dose to sullenly working on a sticker book of cupcakes. Her favorite TV show was "Cake Boss" — she loved looking at all the magnificent varieties of cakes made with ingredients she had never tasted. Although she had perfected a theatrical glower when her mother displeased her — along with a reproachful "Mom!" — the intimacy between them was always visible.Many parents try to keep their children from the knowledge that their allergies could kill them. (When Maya Bodnick, who is 9, told me she could get sick from nuts but knew she could not die, her mother's eyes met mine over her head.) But Tessa was all too aware of what was at stake. When I asked her to describe what would happen if she accidentally ate an allergen, she replied sardonically, "I might take a long nap underground."Tessa was 1 of 35 children in a multiallergy clinical trial who were injected with a powerful drug, Xolair, that suppresses allergic reactions. Xolair, which has been approved for use in patients with asthma (which Tessa also has), blocks the allergic response by inhibiting the IgE antibody that creates anaphylaxis. Using Xolair, Tessa was able to rapidly escalate her doses and complete her treatment in just four months — a fraction of the time it would ordinarily take.My son, Kieran, was too young to take Xolair, so his treatment progressed slowly, and he sometimes had reactions, which meant his updose would have to be postponed. We were mystified to find that after days of giving him a particular dose without incident, a cluster of hives would appear like a swarm of insects on his cheeks, or his face and hands would swell, and he would cry and ask for a Band-Aid or vomit or say, "My food hurt me," and show me his swollen tongue.Each time he had a reaction at home, I was able to reach Nadeau immediately, and she talked me through using various medications to control the reaction. She then stayed on the phone until the reaction subsided, so that we didn't have to spend the night in the E.R. Once, I reached her on her cellphone while she was on vacation with her family in Hawaii. She talked me through the reaction for the better part of an hour and, when the crisis passed, she told me I could call back in the middle of the night if Kieran had any problems later — her cellphone would be by her bed."My family understands I need to be available to my patients 24/7," she said.I rued having interrupted her vacation, but I found out that a half-dozen other parents in the trial had called her with their own questions and crises as well, and that she considered her trip, and indeed all her vacations, to be holidays for her family and "working vacations" for her. She has a missionary temperament, which is fortunate, because the job requires it. One problem with trials involving children is the perennial shortage of saints: of physicians who are not only willing to be constantly available to anxious parents but who have the knack for forging strong alliances with the children themselves to motivate them.Kieran was young enough to love the treatment — going to the hospital with his parents and being petted and praised by Nadeau and the staff. (His sister, Violet, felt left out and was thrilled when we discovered that she had developed a peanut allergy and can be in a trial this spring.) But the older children's feelings about their treatment were more complicated — a problem that has plagued other trials. Single-food-allergy trials in the United States and Europe have reported dropout rates of about 20 percent. Nadeau is intent on avoiding that."If you feel sad or discouraged, you call me — you," she tells the children, leaning in, entwining her pinkie in theirs and asking them to make her "a pinkie promise" that they will take their dose. She tells patients to call her by her first name, and her light, musical voice and lack of a white coat in the clinic all contribute to the magical different-from-other-doctors place she occupies in her young patients' minds. She gives them presents on every possible occasion or lets them pick out books or puzzles or Play-Doh from a bucket in the office. She made a deal with Justine's son, Jack, that if he stuck to his dose of the cashews he loathed, she would arrange for a special tour for him at the zoo where her son, Christopher, volunteered. She conveys to all the kids that they are doing something wonderful — something important that they are the very first to try — but that she knows it is difficult."The main thing is to keep going," she tells patients again and again. "Failure is not an option. We believe that everyone who keeps going succeeds. Everyone."Last May 4, friends and family crowded Tessa's hospital room for her final dose: a full serving of egg, wheat, milk, peanuts and almonds. She ate; an hour passed and then two and then . . . nothing. Everyone squealed and cheered and cried as Kim brought out a celebratory cake. It was the first real cake — an ordinary white bakery cake with fluffy frosting — that Tessa ever had. Three years had passed since Kim first heard Nadeau speak, and her vision that this woman would change their lives had been fulfilled. Tessa was the first person in the world to be desensitized to multiple allergens at the same time.That night, family and friends all went out to a pizzeria (where Tessa asked me what pepperoni was), followed by her first taste of ice cream. Congratulatory texts poured into Kim's phone, and she sent her friends snapshots of something amazing: her family, eating pizza together, like any other family.But profound change is profoundly unsettling. Tessa lost a defining aspect of her identity. Would she not be special anymore? Would she get less of her mom's attention? Tessa still wouldn't eat any of the food that was formerly unsafe at parties or at school. While Tessa told a few close friends about the treatment, she was reluctant to reveal it more widely. When I asked her why, she pursed her lips and studied her nails. Was she afraid that it would make people doubt the severity of her former allergies? "Yeah," she said without looking up.But over the next eight months, Kim watched as her daughter's anxieties began to dissipate. Tessa interacted more with other children in social situations and had her first sleepover. She still has a few allergies (shellfish and some nuts), but they are less burdensome. She had been on the Stanford Junior Olympics diving team, but during the trial, she became too anxious to dive. For months, Kim took her to practice, but she would just sit by the pool, unable to bring herself to get in. This winter, six months after completing the treatment, she decided to try again. She is currently working on a reverse tuck, which involves flipping backward, taking care to avoid the diving board on the way down. "Anyone can do soccer," she told her mom, "but diving is special."Nadeau stresses that oral immunotherapy is still experimental. Her patients are not cured; they are desensitized enough that they can tolerate their former allergens. The reason that she doesn't call it a cure is that the child must continue to eat a maintenance dose of the food every day to avoid regaining the allergy. She often explains to her patients, "If you get off it for three days, you may become sensitive again." An egg-allergy trial found that when patients were taken off the maintenance dose for a month, roughly 60 percent regained the allergy (and there was no way to predict who those patients would be).Eating a full serving of a food they previously regarded as toxic was challenging for many patients. They had to overcome the instinctive revulsion every day. Tessa found milk and cheese weird and eggs so sickening that she once threw up when her mother coaxed her into eating them, so she stuck to egg-white powder. When the children's blood and skin-prick testsbecome negative tothe allergens, which happens somewhere between six months and three years on the maintenance dose, Nadeau believes that a small amount of the allergens (for example, one peanut a day or the amount of egg and milk in one pancake) will be enough to prevent the allergy from returning.For some of the children, when they had their last updose, the desensitization was complete, while for others, ghosts in their immune systems would sometimes surface, and they would have reactions to their maintenance doses. As a precaution, everyone was advised to keep carrying their EpiPens.Jack was one of Nadeau's most difficult cases. In the months following his final updose last June, he suffered severe asthma, unexplained rashes, stomach pains and difficulty eating. He developed an inflammatory condition in his stomach that may or may not have been related to the irritating presence of his daily maintenance dose of 16 cashews. In September, Justine sent me an e-mail: "He is such a good boy, but he is tired. It makes me sad thinking he does not know any different. He is sick more than he is not."At one of Jack's many long appointments, I asked him what it was like to have allergies. He looked down, his long lashes brushing his cheek. "It's hard," he said. I watched his tawny arm, graceful as a ballet dancer's, as he folded the wings of an origami swan he was making. "I don't really like being EpiPenned."A silence fell. His mother's face sank into shadows. He has an unusually sweet and patient disposition; he would sit in the hospital bed without complaint, hour after hour, doing origami, puzzles and workbooks. But I recalled the day I saw him have an anaphylactic reaction during an updose and how agonized Justine was. "It's hard, because you tell your child to trust you and that the hospital is the safest place to be, and then out of nowhere, when their guard is totally down, they have to be EpiPenned," she reflected. She also told me about the day Jack met Brian Hom's son Steven, and after hearing that Steven's brother died of a peanut allergy, Jack asked Justine if he had almost ever died. Justine had to leave the room so he wouldn't see her cry.The thought that his treatment serves the larger purpose of the trial seems to help him to get through it. In the fall, he was scheduled for a procedure in which a camera is slid down his throat to photograph his stomach to see if medication had been effective. When Justine told him it would have to be postponed because he had a cold, he said, "But I have to do it to help the research for other kids, right?"Justine was startled: she had never told him that. "I don't know where he comes from," she said. "He is very focused on helping other kids through his hardship."Justine, meanwhile, never doubted her choice to be in the trial. In an e-mail, she wrote: "And Kari — as always — will always be there for him. She is our godsend. Our angel. I don't have words to describe how I feel about her. . . . This has been the hardest journey of our lives, and she has saved my boy. Many times."Last month, Jack's skin tested negative, and he is no longer allergic to either cashew or pistachios. (Treating cashew also treats pistachio, because the same protein causes both allergies.) He has gained a little weight and grown a small but significant amount, perhaps because his asthma is now moderate rather than severe, which Nadeau says may be a result of his participation in the Xolair trial. But he has to be careful; once he had an anaphylactic episode at school, and if he exerts himself within two hours before or after his dose, he can have a bad reaction. He is currently working on a cookbook to give to kids in the trial of all the ways to disguise disgusting nuts: in sushi, inside an olive or, his favorite, covered with chocolate and mixed into ice cream.Just before Christmas, our son, Kieran, reached his first — and, for us, his most important — milestone. Nine months after we began, he ate 300 milligrams of each of his allergens (the equivalent of more than a full peanut, almond, cashew and hazelnut, as well as a bit of egg) and is no longer allergic to trace contaminants. Although it will take at least another year before he can eat a whole serving, he had become 300 times less allergic than he was at the start of the trial. When Violet's peanut allergy is treated, our family can take down the sign on our front door forbidding anything made with eggs or nuts and welcome Girl Scout Cookies.After Kieran's updose in the hospital that day, we went down to the cafe to celebrate. We sat near the hospital's glittering Christmas tree, listening to piano music, and I bought a turkey sandwich for us to share. For the first time in his life, I didn't have to worry whether the bread had been cut with a knife or made on a surface that had also been used for mayonnaise or peanut butter. Kieran liked making a game of sharing the sandwich — a bite for him and a bite for me — but then he said, "I wish it all mine," and when I told him he could have it, he slid off my lap and hopped up and down with joy.The current studies at Stanford are in the analysis phase. The next and final phase of Nadeau's multiallergy trial, which is in development, will very likely involve more patients and take place at multiple allergy centers across the country. Then, if that is successful and the treatment is approved by the F.D.A., it may eventually become standard. Research in Nadeau's lab has found that treating allergies actually changes the genes by epigenetics (a chemical modification of the genes that does not affect the actual DNA sequence), so desensitizing children may reduce the likelihood that they will pass on the disease to their children. One day, perhaps, fatal anaphylaxis may become a sorrow associated with an earlier age, like dying of appendicitis or polio.I sometimes have an image of Kari Nadeau taking Kieran and Jack and Tessa and the other children by the hand and guiding them step by step, dose by dose, away from the grave. Of course, none of us will ever know which, if any, of our children would have slipped over the edge, but we do know the treatment rescued us from a lifetime of peering into the abyss.<nyt_author_id><div class="authorIdentification" style="margin-bottom: 2.8em; "><p style="color: rgb(0, 0, 0); font-size: 15px !important; margin-top: 0px; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; line-height: 24px; font-style: italic; font-family: Georgia, serif; font-variant: normal; font-weight: normal; letter-spacing: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); position: static; z-index: auto; "><a href="mailto:melthernstrom@gmail.com" style="color: rgb(102, 102, 153); text-decoration: none; font-size: 15px !important; line-height: 22px; ">Melanie Thernstrom</a> is a contributing writer for the magazine and the author, most recently, of ''<a href="http://www.melaniethernstrom.com/painchronicles.html" style="color: rgb(102, 102, 153); text-decoration: none; font-size: 15px !important; line-height: 22px; ">The Pain Chronicles</a>,'' about the science and meaning of pain.</div></nyt_author_id></div><a href="http://www.nytimes.com/2013/03/10/magazine/can-a-radical-new-treatment-save-children-with-severe-allergies.html?ref=magazine&pagewanted=all">http://www.nytimes.com/2013/03/10/magazine/can-a-radical-new-treatment-save-children-with-severe-allergies.html?ref=magazine&pagewanted=all</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "> </div>

Can a Radical New Treatment Save Children With Severe Food Allergies? - NYTimes.com

For nine years, the greatest challenge Kim Yates Grosso faced each day was keeping her daughter Tessa safe. Tessa was so severely allergic t...

Painkiller-abuse proposal divides healthcare community, even in same hospitals | cleveland.com

12:28 PM Tukiyooo 0

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><div style="color: rgb(54, 54, 54); font-family: Georgia, serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 24px; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); position: static; z-index: auto; ">Doctors at top health centers including the Cleveland Clinic and University Hospitals want the U.S. Food and Drug Administration to toughen rules for prescribing powerful painkillers like OxyContin and similar opioids, saying this could curb addiction and drug abuse.Yet there is pushback -- from, among others, medical professionals at some of the same hospitals, including the Cleveland Clinic, public records and interviews show.These doctors and clinicians say they, too, want to halt addiction and deaths from the over-consumption and abuse of opioid painkillers, which the<a href="http://www.cdc.gov/homeandrecreationalsafety/rxbrief/" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; "> U.S. Centers for Disease Control calls an epidemic</a>. The CDC lists Ohio as among the states with the highest rate of overdose deaths from OxyContin and similar drugs that use synthetic or natural versions of the opium poppy to suppress pain -- and can create a sense of euphoria and addiction in some people. Included in this drug class is not only OxyContin but also Vicodin, Percocet, methadone and codeine, the CDC says.But some medical specialists worry that more harm than good could come if patients with long-term pain from injuries or medical conditions cannot get relief, especially if opioids are only recommended for patients in severe rather than moderate pain -- a personal and subjective call, some say. Doctors might be able to prescribe "off-label" uses for select patients, depending on what the FDA decides, but this would restrict how drug companies market the painkillers and could make insurers reluctant to pay.It could lead to patients lying to their physicians about their pain in order to meet higher thresholds, and to increased illegal street sales -- or even to suicide if untreated pain becomes unbearable, according a letter submitted to the FDA by one Cleveland Clinic pain-management nurse and researcher.Nonsense, responds Dr. Andrew Kolodny, a Brooklyn, New York psychiatrist who treats addiction and is president of <a href="http://www.supportprop.org/index.html" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">a group lobbying for more restrictive opioid prescribing</a>. He says the painkillers are over-prescribed and used for purposes far beyond what research supports.He called the suicide claim "totally bogus," saying suicide can result from the severe anxiety and panic attacks associated with drug withdrawal -- a problem that stems from addiction to painkillers, he said, not failure to treat pain appropriately."We're not trying to take these people's opioids away from them, we're trying to prevent new starts," he told The Plain Dealer.The director of the Cleveland Clinic's Neurological Center for Pain, <a href="http://www.rsdfoundation.org/en/en_foundnews2.html" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Dr. Edward Covington</a>, is among those backing the <a href="http://www.citizen.org/documents/2048.pdf" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">petition </a>submitted by Kolodny and the group, Physicians for Responsible Opioid Prescribing, or PROP, last July. The group says that "an increasing body of medical literature suggests that long-term use of opioids may be neither safe nor effective for many patients, especially when prescribed in high doses."The group says that misperceptions among clinicians "lead to over-prescribing and high-dose prescribing." It wants the FDA to strike the term "moderate" from prescribing indications for non-cancer pain. It also wants the drug regulatory agency to recommend a maximum daily dose, equivalent to 100 milligrams of morphine for non-cancer pain, and to limit patients' continuous use to 90 days maximum.Other doctors who signed the PROP letter to the FDA include <a href="https://casemed.case.edu/fammed/faculty/Kurt_Stange.html" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Kurt C. Stange</a>, a medical professor at Case Western Reserve University, and <a href="http://www.citizen.org/Page.aspx?pid=2971" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Sidney Wolfe</a>, director of Public Citizen's Health Research Group, a national public interest group. Writing to the FDA separately in support was <a href="http://www2.kenes.com/nwac/sci/pages/bio.aspx?HID=52" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Dr. Salim Michel Hayek</a>, an anesthesiologist and pain specialist at University Hospitals."The major question is, are we helping the patients with these medications?" Hayek said in an interview last week. Evidence suggests that for patients recovering from surgery or with painful end-of-life illnesses, opioids can be effective, even a godsend, he said. But they are questionable in other uses, such as regular treatment of chronic back pain, and the tolerance buildup requires higher doses and increases risks, Hayek said.Yet Dr. Riad Laham, an anesthesiologist and pain management specialist at the Cleveland Clinic's Hillcrest Hospital, <a href="http://www.regulations.gov/#!documentDetail;D=FDA-2012-P-0818-0334" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">wrote to the FDA</a> in late September in apparent support of a group of pain doctors who disagreed with PROP. Laham's correspondence, like other documents cited in this article, was obtained from electronic FDA public records, and he and others at the Clinic did not respond to requests for interviews. He told the FDA, according to its electronic records, that PROP's petition was "short sighted and plain deleterious. Opiates have given some chronic pain sufferers their life back. It is a part of a multimodal approach to treat this population."<a href="http://anesthesiology.osu.edu/4522.cfm" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Dr. Constantino Benedetti,</a> a professor in the clinical department of anesthesiology at Ohio State University, signed a similar letter to the FDA as a member of the American Pain Society. The society said the PROP proposals "will not accomplish the intended goals, but instead have unintended negative consequences for patients including but not limited to untreated pain and loss of access to individualized care." The letter also said that "opioids achieve good pain control with minimal adverse effects for some patients but not others. At present, we lack adequate evidence to predict which patients are which."Holding a similar view was <a href="http://mediccast.com/nursingnotes/2011/09/pain-management-nurse-esther-bernhofer-shares-her-nursing-career-path/" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">Esther Bernhofer</a>, a registered nurse who specializes in pain management and conducts pain-management research at the Clinic. She <a href="http://www.regulations.gov/#!documentDetail;D=FDA-2012-P-0818-0221" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">warned the FDA </a>of poor consequences if opioids are only considered appropriate for severe pain but not moderate pain -- words that "may have little meaning.""If the intent with this legislation is to decrease the amount of abuse, then it will surely backfire and only harm the people who really need professional help," she said in a letter to the agency. "It will encourage hoarding of medication, lying to a practitioner regarding the severity of pain, and perhaps even leading to further misuse of opioids by persons whose pain is not adequately controlled through legitimate routes."She added that Washington state, which has adopted stringent standards, "has seen an upsurge in patients who can find no relief and suicides. We are literally trying to solve a societal problem on the backs of legitimate patients."Even the American Cancer Society's Cancer Action Network <a href="http://docketwrench.sunlightfoundation.com/#document/FDA-2012-P-0818-0337" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">cautioned </a>against over-regulating, despite language in PROP's proposal showing it does not want to restrict opioids for cancer patients. The action network, an advocacy arm of the cancer society, said it is concerned about cancer survivors who may require painkillers for subsequent conditions."We don't tend to focus on cancer pain versus non-cancer pain," Keysha Brooks-Coley, the organization's director of federal relations, said in an interview last week. "We focus on the issue of pain in general and access to pain medications."This split among medical professionals underlies how difficult the issue is for patients, whose treatment can depend on which side of the divide a physician falls."Not having access to it would put me in a lot of pain," said Paula Chamot, a Cincinnati resident who has<a href="http://www.regulations.gov/#!documentDetail;D=FDA-2012-P-0818-0502" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; "> asked the FDA to reject PROP's request</a>. Operations to treat a nerve injury left her with complex regional pain syndrome in her right arm, she told The Plain Dealer. Under a doctor's care, she supplements pain patches with Percocet. Although she must deal with the effects of detoxification including anxiety when she eases off the medication, the pain would be a much worse alternative, she said.Yet in early February, a former teacher from Ontario, Canada, Ada Giudice-Tompson, told an<a href="http://www.fda.gov/Drugs/NewsEvents/ucm326450.htm" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; "> FDA hearing</a> about her son, Michael, who went to sleep one night in 2004 while on prescription painkillers and never woke up. Her testimony was part of a two-day informational hearing."We are legally providing heroin-like drugs, and should expect nothing less than an epidemic of addiction and death along with poor pain management," she said.The FDA has not decided what to do about opioids. In a <a href="http://www.regulations.gov/#!documentDetail;D=FDA-2012-P-0818-0694" style="color: rgb(48, 92, 182); text-decoration: none; font-weight: bold; ">letter Jan. 22</a>, it told PROP that is "has been unable to reach a decision on your petition because it raises significant issues requiring extensive review and analysis by agency officials." The agency did not say when it expects to reach a decision.Meantime state officials in Ohio, where OxyContin addiction has plagued several rural communities, are considering measures independent of the FDA. No date has been announced. But the state standards would be voluntary rather than mandatory, said Dr. Theodore Wymyslo, director of the Ohio Department of Health.They would include a recommendation that doctors or nurses closely monitor anyone for whom they prescribe a painkiller equivalent to 80 milligrams or more of morphine, and for more than 90 days. There would also be a recommendation that these patients see a pain-management specialist. The 80-milligram threshold is lower than the proposed federal 100-milligram prohibition for certain patients, and the 120 milligram standard mandated in Washington state, Wymyslo said."Our group thought 120 milligrams was too high," he said. "We thought that 120 milligrams is a lethal dose for some people."Even groups that oppose the PROP proposal have agreed to Ohio's standards, the health director said, although the state's medical licensing boards still must approve. "The fact that we came to consensus is a modern-day miracle," he said.But he acknowledged a key reason for this consensus: Ohio's standards would be voluntary.<div> </div></div></div><a href="http://www.cleveland.com/open/index.ssf/2013/03/proposed_painkiller-abuse_rule.html">http://www.cleveland.com/open/index.ssf/2013/03/proposed_painkiller-abuse_rule.html</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "> </div>

Painkiller-abuse proposal divides healthcare community, even in same hospitals | cleveland.com

Doctors at top health centers including the Cleveland Clinic and University Hospitals want the U.S. Food and Drug Administration to toughen ...

Brush Piles, Birds on a Wire, and Blinds

12:00 PM Tukiyooo 0

This is the third article in a series on WILD School Sites, or outdoor classrooms. WILD School Sites are locations that can be used by students, teachers, and the school community as places to learn about wildlife and the environment. The first thing to do when developing a site is to formulate a plan. You can contact your district <a href="http://www.dnr.state.oh.us/Home/ContactUsStandIn/tabid/18270/Default.aspx" target="_blank">Wildlife Communication Specialist</a>, who can walk you through the process to help ensure success.   <h3>So what type of project should you do?</h3>Remember, no two sites are the same, so each site will consist of different projects. Available resources, such as time, money, space, and labor, will also play a role in what projects are chosen. Last month’s article focused on bird feeders as an inexpensive and quick way to get your site up and running. This month we will look at a few more projects which can be completed at any time of the year and at very little expense. <h3> Brush Piles or an Unkempt Mess?</h3> Constructing brush piles is another low cost way of adding habitat to almost any site. Properly constructed brush piles are a great source of cover and protection for a myriad of wildlife species, including rabbits and songbirds. However, the line between a habitat project and a pile of yard waste is sometimes in the eye of the beholder. A little neighborly courtesy can go a long way toward preventing complaints. Before constructing brush piles, have the students write cards or letters to the neighbors explaining what you are doing, and how it will benefit local wildlife. <table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjBgPny9YfOn4DCIX7HmUkwY-hyJrHb4GBIApDFXrvndOnLqmYs5NlrYbbwgrB33qjPxnohttQ0Q8S7_uoj_uPi1i7se7sCy0anykuReHD7i4hZKmAElCSHC4BMA8upLQCqX2bLeURxPRzX/s1600/Leggett+Street+10.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjBgPny9YfOn4DCIX7HmUkwY-hyJrHb4GBIApDFXrvndOnLqmYs5NlrYbbwgrB33qjPxnohttQ0Q8S7_uoj_uPi1i7se7sCy0anykuReHD7i4hZKmAElCSHC4BMA8upLQCqX2bLeURxPRzX/s320/Leggett+Street+10.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Legget Street Elementary, Wauseon, OH</td></tr></tbody></table> When constructing a brush pile, begin by building a foundation by crisscrossing logs in a log cabin fashion. This frame will support limbs and branches which will provide protection from predators, and still maintain useful cavities for wildlife to hide in. If no logs are available, an artificial base can be constructed using cement blocks. Continue to add branches and limbs until the pile is 5-10 feet high. Brush piles will usually last 3 to 5 years, before they will need to be rebuilt. <h3>Birds on a Wire</h3>Perching wires are a great low cost project for your WILD School Site. They are cheap to construct, can be done at any time of the year, and provide a lot of learning opportunities for kids. Have you ever discovered an errant plant growing in an unexpected spot? Ever wonder how all those trees get started along fencerows? The answer: birds. Many species of plants have adapted a unique way to spread their seeds. They provide birds with a tasty fruit which contains seeds. Those seeds, however, cannot be digested by the bird. When the seeds pass through the birds, they get deposited in new locations, fertilizer included. <div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEizvW21WYpI5CQGht9aN63fx4SORtv7Em1hM6xsXaTt0r3bwV-2xygGHJhxsEpvNB2k-cNHaTmpijUWy5u3ugczJcK1gxbntKqaXbob0jifUjX8LXbETBgicjCEhvzkXNKV5-dOsw1LCFqS/s1600/perching+wire.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="225" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEizvW21WYpI5CQGht9aN63fx4SORtv7Em1hM6xsXaTt0r3bwV-2xygGHJhxsEpvNB2k-cNHaTmpijUWy5u3ugczJcK1gxbntKqaXbob0jifUjX8LXbETBgicjCEhvzkXNKV5-dOsw1LCFqS/s320/perching+wire.jpg" width="320" /></a></div> To construct a perching wire, simply stretch a cable or wire between posts that are around 10 feet apart. Sometimes old cable or wire can be found lying around and reused. Care should be taken to ensure that the cable is in an area where kids won’t unknowingly run into it. Another option is to place the wire high enough off the ground so kids can’t become entangled. Next, simply clear a strip of vegetation three feet wide underneath the length of the wire. A rototiller works great, but isn’t necessary. Have the students keep records on what species of birds they see on the wire. Then have them record what types of plants begin growing underneath the wire to learn what foods those birds prefer. <h3>Observation Blinds</h3><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg8vQUJU9Nq_vdeYa2vXp1hpd7wy4Zrxwv7LEUg5_tTM9HeYIveg4u68nqNubXGN6yudxVgGerFl-Ze7Y1Yaj3GreJPJzRfe8bi9kwfaUUUWkJNAlrL70jZA-fQ2Bm8D8VbcHPD_AkEWOHM/s1600/henn%2520wildlife%2520blind%25201.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg8vQUJU9Nq_vdeYa2vXp1hpd7wy4Zrxwv7LEUg5_tTM9HeYIveg4u68nqNubXGN6yudxVgGerFl-Ze7Y1Yaj3GreJPJzRfe8bi9kwfaUUUWkJNAlrL70jZA-fQ2Bm8D8VbcHPD_AkEWOHM/s320/henn%2520wildlife%2520blind%25201.jpg" width="232" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;"><a href="http://www.cloverleaflocal.org/protected/ArticleView.aspx?iid=6GG22AB&dasi=330Y" target="_blank">Cloverleaf Elem. School, Lodi, Ohio</a></td></tr></tbody></table>Observation blinds, or bird blinds, are a way for kids to become “invisible” to the wildlife using your site. Blinds can be more costly than the other projects we have discussed so far, but can easily be constructed at any time of the year and during any phase of the plan. Observation blinds are more crucial for sites that are located in wide open areas far from classrooms. Also, let’s face it, sometimes kids can have a little trouble keeping still for longer periods of time. Blinds offer a solution for kids to observe and record wildlife. <div style="text-align: right;"> </div>Blinds can be located anywhere wildlife frequent: bird feeders, brush piles, around ponds, and gardens. Observation blinds can be temporary or permanent, large or small, cheap or expensive. For a blind that younger kids can help construct, first erect a wooden frame and cover it with chicken wire. Have the kids help attach leaves, sticks, and grasses to the wire. More elaborate blinds can be constructed using lumber for the side. Whatever type of blind you choose to construct be sure to leave a small open area for observation. A small bench or chairs add a nice finishing touch.    <h3>A Final Thought</h3><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgrHxOziw3LtvcYgnmqXUgCHdSgL1piihAzyvspIz2wWWv1od4bPovZ64Og8i1ob3Ia_kviqYAYzc2ISTOzGetTDciaRKX9QlRk2joWZwojwCK5EsdR0MRF2PTZIOGW09HUYiIRPlHyrTS6/s1600/WSS+sign.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgrHxOziw3LtvcYgnmqXUgCHdSgL1piihAzyvspIz2wWWv1od4bPovZ64Og8i1ob3Ia_kviqYAYzc2ISTOzGetTDciaRKX9QlRk2joWZwojwCK5EsdR0MRF2PTZIOGW09HUYiIRPlHyrTS6/s320/WSS+sign.jpg" width="235" /></a></div>Although most WILD School Sites contain multiple projects that can take years to develop from start to finish, brush piles, perching wires, and observation blinds offer an opportunity to start educating youth about Ohio’s wildlife at any time of the year. They are relatively inexpensive, easily constructed, and can be used at virtually any site. For more information about these projects or other WILD School Site projects, contact your district’s <a href="http://www.dnr.state.oh.us/Home/ContactUsStandIn/tabid/18270/Default.aspx" target="_blank">Wildlife Communications Specialist. </a>

Brush Piles, Birds on a Wire, and Blinds

This is the third article in a series on WILD School Sites, or outdoor classrooms. WILD School Sites are locations that can be used by stude...

Teach This! Teaching with lesson plans and ideas that rock 03/08/2013

11:30 AM Tukiyooo 0

<ul class="diigo-linkroll"> <li> <a href="http://www.nanoogo.com">Nanoogo - Home of the Most Creative Kids on the Planet</a> A very interesting platform that teachers of younger students are using for them to create and share what they are doing. It seems to be more visually based rather than text based. It is free and right now has two versions, one for the classroom and another for home. It is in beta and if you sign up now it is free. Would love to hear what some of you think. tags: <a href="https://www.diigo.com/user/coolcatteacher/elemchat">elemchat</a> <a href="https://www.diigo.com/user/coolcatteacher/education">education</a> <a href="https://www.diigo.com/user/coolcatteacher/apps">apps</a> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/blogging">blogging</a> <a href="https://www.diigo.com/user/coolcatteacher/web 2.0">web 2.0</a> <ul class="diigo-comments"> </ul> </li> <li> <a href="http://www.myhistro.com">Create Free Interactive Timelines – Stories Displayed on Maps | myHistro</a> Very interesting app if you're using Edmodo and have ipads. Here's what it will do as per the company who contacted me: "It's a versatile mapping tool for creating timelines, and an assessment platform for Edmodo users.     myHistro Extended in a nutshell.  - What makes it better than other apps out there? Its comprehensive digital archive with stories created by historians. An unique way of generating tests. Hassle free and easy grading system and evaluation of students’ answers." MAny teachers are using Edmodo and Timelines are important prewriting and graphic organizing tools. I'm very fascinated to see how this works and will see if there is someone out there using it so we can link to it from my blog.  - Who's it for? Teachers. First and foremost History, Social Studies and Geography teachers. And for everyone else, who are looking for innovative ways teaching their subjects through dynamic storytelling.   - What is the coolest feature? Generating tests with a few clicks. Removing the location, time, description or/and the title from all the public stories, and forming it into tests.  tags: <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/edmodo">edmodo</a> <a href="https://www.diigo.com/user/coolcatteacher/assessment">assessment</a> </li> </ul>Posted from <a href='https://www.diigo.com'>Diigo</a>. The rest of my favorite links are <a href='https://www.diigo.com/user/coolcatteacher'>here</a>.

Teach This! Teaching with lesson plans and ideas that rock 03/08/2013

Nanoogo - Home of the Most Creative Kids on the Planet A very interesting platform that teachers of ...

Jerusalem, My Happy Home: Part 11

10:58 AM Tukiyooo 0

<div class="MsoNormal">There was unrest in Jerusalem today. http://www.reuters.com/article/2013/03/08/us-palestinians-israel-violence-idUSBRE9270GQ20130308 There may have been several things going on. I have heard different versions. But the main thing was a funeral at the Al Aqsa Mosque for a Palestinian inmate killed in prison recently. The funeral was accompanied with a major protest. That led to a confrontation involving the use of rocks and firebombs by the Palestinians and tear gas and water canons by the Israelis. We saw a lot of police on the streets, some on horseback, and there were still water canons around. The police were following Muslims in traditional dress pretty closely, checking them out. Tonight there is a big demonstration happening in Manger Square. In a way it all seems fitting for the visits we made today. But I’m glad we visited the Temple Mount yesterday instead of today!</div><div class="MsoNormal"> </div><div class="MsoNormal">We began this morning at the Franciscan church at Bethphage on the Mount of Olives. The Church is in the general vicinity where the village likely stood and where Jesus would have begun his Palm Sunday ride into Jerusalem. The present church is 19th Century but is built over the ruins of a Crusader chapel.<o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">We then went a-ways down the hill to the Church of Dominus Flavit (the tear of the Lord) where Jesus prophesied the destruction of Jerusalem because she would not follow his way of peace. It was a moving view of the City. Of course we don’t’ know exactly where this happened, but it was on the Mount of Olives. From the Mount of Olives you look across the Kidron Valley (deep but not wide) to Jerusalem, specifically to the Temple Mount. Jesus would have been looking across at the Temple when he spoke.<o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">Next we visited Gethsemane. This has been high on my list, first and foremost because Gethsemane is not a replica. It is the very garden where Jesus prayed. But it proved even better than I expected. Not only was it the same plot of earth, some of the olive trees were the same trees! Who knew they lived so long? In fact some of these trees had been around a long time when Jesus was there. The prayer in Gethsemane was the most compelling moment in the life of Jesus that led me back to the Church so long ago now. I realized I could meditate a long time to grind away at my ego; but he did it right there by surrendering to God’s will. There is, of course, a church at Gethsemane, its art and architecture well suited to the mood of agony in the garden. “Agony,” in this story does not mean intense suffering. It means struggle.<o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">Then we visited the Benedictine Church of the Dormition of the Virgin Mary. I’ve already expressed my skepticism about linking that story to Jerusalem. JMHH Part 10. But this Church is beautiful and has some of the most compelling Marian art I’ve ever seen. It was very special to be there. <o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">This afternoon, we went to a Church that commemorates the Last Supper. There is a room constructed to be the sort of place such a meal might happen and where the disciples might await the coming of the Holy Spirit. It is set above a Memorial to King David. <o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">Then we went to the Church of St. Peter in Galicantu (cock’s crow) located on the Eastern slope of Mt. Zion just outside where the wall of Jerusalem would have stood in Jesus’ day. This Church is associated with the Trial of Jesus before Caiaphas. The story is that this is the house of Caiaphas, that Jesus was tried here, that Peter denied him three times here before the crowing of the cock, that Jesus was beaten by the Temple guards here, and that he was kept in the pit until he was delivered to Pilate.<o:p></o:p></div><div class="MsoNormal"> </div><div class="MsoNormal">Authenticity check: this is not a house. It is a Church but it does have a real dungeon underneath. This Church was built in 1931, but it replaces a medieval Crusader church, which in turn was built over the ruins of a Byzantine Church built in 457 C.E. The Church has commemorated the trial and sufferings of Jesus here since the mid 5th Century. The choice of this location was not arbitrary. It is believed that Caiaphas’ house was in this vicinity. And this place has a real dungeon underneath where imprisonments and scourgings happened in the 1st Century. So it does have a decent claim to being the place of Jesus’ trial. The dungeon part may or may not have figured into Jesus’ story. Christians read Psalm 88 about being in the pit. But it’s a bit of a stretch to find that happening in the Gospel accounts. If you do imagine Jesus in the pit, or anyone else for that matter, it is really grim.<o:p></o:p></div>

Jerusalem, My Happy Home: Part 11

There was unrest in Jerusalem today. http://www.reuters.com/article/2013/03/08/us-palestinians-israel-violence-idUSBRE9270GQ20...

Could This App Treat Depression? | Popular Science

10:30 AM Tukiyooo 0

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; " class=""><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">A new company with a Harvard psychiatrist as inventor-in-residence says it's got the research to back up its claims.</div><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""><div style="margin: 0.5em 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="readableBigImage"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhErDTvWviart1NjN0szrZOSfuqGUBBBblaYHXGzz2i6UbLNzFcUYHXyjCidTk5VP0p5qRGL6ahkuy4AQMzXSUDIIPlw-xBd0-7aHlpzlIBkEhr7ulHqomS-LtUqXBjCuwJQ97P_3qyjk/s1600/braintracerproto2-731786.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5853041554517929346" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhErDTvWviart1NjN0szrZOSfuqGUBBBblaYHXGzz2i6UbLNzFcUYHXyjCidTk5VP0p5qRGL6ahkuy4AQMzXSUDIIPlw-xBd0-7aHlpzlIBkEhr7ulHqomS-LtUqXBjCuwJQ97P_3qyjk/s320/braintracerproto2-731786.jpg" /></a></div><div style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">BrainTracer Game Prototype BrainTracer</div></div><span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class="">Diego Pizzagalli spent a good chunk of 10 years at Harvard doing what most professors at elite institutions do: research. Specifically, research on depression. He's fMRI'd and EEG'd a lot of gray matter, but most of his work got stuck in the lab and never evolved into any real-world application. Then he developed something that was too good to let collect dust in the hallowed halls of academia: software that he says could help treat depression.<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">Now with the help of the Baltimore-based startup incubator Canterbury Road Partners, Pizzagalli is set to turn his lab invention into an app. MoodTune will be a series of simple games that when played regularly, can help treat depression, Pizzagalli and his colleagues say. Turn on the app for 15 minutes a day, play through some games, and maybe it could help. Maybe, they say, in some cases, it'd be all a depressed person would need. Could something that simple actually work?<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""><strong style="margin: 0px; padding: 0px; border: 0px; font-weight: bold; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">* * *<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">Pizzagalli started working on depression in 1999 and released some of his most important papers in 2001. The papers focused on "biomarkers," signals of response in the brain to antidepressants and psychotherapy. Take a peek inside the brain, and you can see areas light up--or fail to light up--in response to treatments. Whether an area lights up or not predicts, with considerable accuracy, whether a treatment works, he says.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">So, the thinking goes, what we if we illuminate those regions another way? The brain could readjust appropriately without the need for a pill. The anterior cingulate cortex is associated with depression and also works when snap decisions need to be made, Pizzagalli says, so perhaps having someone make snap decisions would help treat depression. He developed desktop software in his lab to test it out and was happy enough with the results to delve deeper into the technology.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">Software like that could make for a "bottom-up" approach to depression treatment. It could "strengthen the circuitry" of the ruminative brain. It could break the cycle of dwelling seen in so many depressives. It could be the first treatment of its kind to go on the market. But to turn the research into anything tangible took some extracurricular assistance.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""><strong style="margin: 0px; padding: 0px; border: 0px; font-weight: bold; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">* * *<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">Universities are well-equipped to do research: they have large staffs, top-shelf gear, and the greatest minds in their fields in a condensed area. And after the research is done? Well, they still have large staffs, but that stops being an asset. Sean Pool, a general partner at Canterbury, put it like this: "By and large, universities are these massive, inertial bureaucracies." So why not take the inventors out of the Ivory Tower, team them up with entrepreneurs, have them form lean, Silicon Valleyish startups, and get their products to market faster?<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">There are plenty of 'health' apps out there that don't function much better than a placebo, if that--but Pizzagalli insist there's the science to back up BrainTracer.With Pizzagalli, Canterbury Road is doing precisely that. Pizzagalli originally approached Harvard about marketing the technology behind his research, but the process stalled until he moved to the university's McLean Hospital, where administration suggested he partner with Canterbury. Canterbury set up a venture company for his research (Venture Launch Team No. 1), offered the CEO position to Andre Konig, an "entrepreneur in residence" who's spent a decade working in consulting and more recently in private equity, and soon they had a name for the business (BrainTracer) and the prototype app (MoodTune). As for what Canterbury gets out of it? It holds a small stake in the venture.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class="">Immediately, Konig and Pizzagalli got to work developing a business model, shopping around for investors, and designing a prototype. BrainTracer, if all goes according to plan, will launch its flagship app, MoodTune, by the end of spring. The idea is for Pizzagalli and other psychologists' research to create an app that can help combat depression. On its face, that doesn't sound like the most medically credible idea--there are plenty of "health" apps out there that don't function much better than a placebo, if that--but Pizzagalli insists there's science to back it up. BrainTracer officially launched Monday, but before the app is released, Pizzagalli and Konig will also send it through a medical trial to test for its effectiveness. The pair is hoping to snag an National Institute of Health grant for "cognitive training" software.<p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class=""><strong style="margin: 0px; padding: 0px; border: 0px; font-weight: bold; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">* * *<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">When MoodTune is out, this is how it'll work: You'll open the app and be directed to a simple game (there are "six or seven" games so far Konig says.) The images you see here are from the prototype, but the final version will probably be similar. Here's the example Pizzagalli gave of a game that could be used for a "workout." A face appears onscreen. The user--or patient, depending on your thoughts about the app--looks at the face as words flash above it: "Happy." "Happy." "Sad." "Happy." The user gets slammed with some serious cognitive dissonance as they try to reconcile the faces and words. After the user is done, he gets a review of his score for the game, as well as his overall progress in treatment.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""><div style="margin: 0.5em 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="readableBigImage"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjTnUbC2fGd_uweX1EmkPzWnaoN6u_yQwAHiRYiCmf_izRk5jJ-NJLiUBNmi_I775BMXeTLK-xDW-JdDU5W3z5BixweSLCSegrWdCMrRPoWvyRuGR8EC-RRe9nzIylijeRDvxvvWeBF3VE/s1600/braintracerproto1-733521.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5853041558062840770" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjTnUbC2fGd_uweX1EmkPzWnaoN6u_yQwAHiRYiCmf_izRk5jJ-NJLiUBNmi_I775BMXeTLK-xDW-JdDU5W3z5BixweSLCSegrWdCMrRPoWvyRuGR8EC-RRe9nzIylijeRDvxvvWeBF3VE/s320/braintracerproto1-733521.jpg" /></a></div><div style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">BrainTracer Interface Prototype: BrainTracer</div></div><span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">An exercise like that can cause certain parts of the brain to work overtime, Pizzagalli says. It's enough, he says, to give certain parts of the brain a "tune-up" and enough, apparently, when done for 15 minutes every day, to counteract some of the symptoms of depression.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">Pizzagalli and Konig aren't the only ones looking into similar "cognitive training" approaches in mental health. A 2003 study into cognitive training techniques in schizophrenia noted that the approach showed "effective components that hold promise for improving cognitive performance." Multiple studies in the <a target="_blank" href="http://jama.jamanetwork.com/article.aspx?articleid=204643" style="margin: 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: underline; vertical-align: baseline; color: rgb(40, 40, 40); text-align: inherit; cursor: pointer; " class="">Journal of the American Medical Association</a> have found modest increases in brain function apparently spurred by cognitive training.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">Still, the idea that brains can be successfully "trained" is more than a little controversial. Lumosity, a series of "brain training" software products, has been maligned for selling digital snake oil. The software is pitched as a set of simple games that can improve everything from memory to concentration (and that its games are backed up by neuroscience, too). When the consumer groupWhich? asked a panel of scientists to explain the effectiveness of neuro-gadgets, including Lumosity, the scientists concluded there was <a target="_blank" href="http://www.guardian.co.uk/science/2009/feb/26/brain-training-games-which" style="margin: 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: underline; vertical-align: baseline; color: rgb(40, 40, 40); text-align: inherit; cursor: pointer; " class="">no evidence</a> to back up the claims. At best, they said, the training would help about as much as a crossword puzzle or round of Space Invaders--nothing especially brain-empowering about it.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""><strong style="margin: 0px; padding: 0px; border: 0px; font-weight: bold; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: none; vertical-align: baseline; color: inherit; text-align: inherit; " class="">* * *<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">So what's different? Precision, for one, Pizzagalli says. Instead of trying to play the full court, they take a position: the app, unlike Lumosity, only focuses on depression. That focus gives it an edge. Pizzagalli is also shooting for openness. MoodTune will have a dashboard feature that can give the users more information about the app and updates on their progress. Users will also be able to respond to BrainTracer about the app, letting the team know how well it's working.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">A 2003 study into cognitive training techniques in schizophrenia noted that the approach showed 'effective components that hold promise for improving cognitive performance.'Either way, expectations are at least a little tempered. The app, they say, could only work on its own for people on the margins of clinical depression, not meeting all the criteria to make it official but still exhibiting some of the symptoms. Modest gains are what the team is hoping for, but they're optimistic enough to have laid out a business model for the app. And if the technology isn't the same as Lumosity's, the tiered pricing model is at least similar. Pay for access for a few months with x dollars, or upgrade to a few more months for y dollars. For BrainTracer, that might mean tiers from $30 to $50 monthly.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">That could make it cheaper than the cost of depression medication (and possibly more fun to take).<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">That's in the pro column. In the minus column, the question might eventually be: How do we sell this app? There are similar-sounding apps out there based on shaky science at best. On Google Play, for instance, you can <a target="_blank" href="https://play.google.com/store/apps/details?id=com.ihunda.android.binauralbeat&hl=en" style="margin: 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: underline; vertical-align: baseline; color: rgb(40, 40, 40); text-align: inherit; cursor: pointer; " class="">download</a> so-called "binaural beats," apps designed to alter one's state of mind. Need some creativity? Tap. How about just some relaxation? Tap-tap.<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin: 1em 0px 0px; padding: 0px; border: 0px; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); " class="">Apps like that don't have the science to back them up, and certainly didn't go through a trial process in line for an NIH grant, so there'll be some pressure for MoodTune to distinguish itself from them. The dashboard system in MoodTune could help out, Konig says. After each game, the users can have the science behind the game explained to them. That's something a lot of other apps can't offer--or at least can't offer as easily. They'll also be mostly marketing the app to institutional clients like government organizations, rather than just individuals, meaning the standard of proof for the app is higher but it'll reach more people once the bar is reached. (Along with investors, they're looking to the<a target="_blank" href="http://www.indiegogo.com/projects/345876?show_todos=true" style="margin: 0px; padding: 0px; border: 0px; font-weight: inherit; font-style: inherit; font-size: 18px; font-family: inherit; letter-spacing: inherit; text-decoration: underline; vertical-align: baseline; color: rgb(40, 40, 40); text-align: inherit; cursor: pointer; " class="">crowdfunding site Indiegogo</a> to help pay for it.)<span style="color: rgb(40, 40, 40); font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 27px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); display: inline !important; float: none; " class=""><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class="">On the other hand, if there's a market for enhancing creativity, there's definitely a market for fighting depression. Tens of billions in productivity costs are lost every year to the illness, and fighting it is a multi-billion dollar industry itself. Plenty of people out there are willing to try out new treatments, whatever they look like.<p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: normal; font-style: normal; font-size: 18px; font-family: 'Palatino Linotype', Palatino, 'Book Antigua', Georgia, serif; letter-spacing: normal; text-decoration: none; vertical-align: baseline; color: rgb(40, 40, 40); text-align: left; font-variant: normal; line-height: 27px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(245, 245, 245); position: static; z-index: auto; " class=""> </div><a href="http://www.popsci.com/technology/article/2013-02/depression-app" class="">http://www.popsci.com/technology/article/2013-02/depression-app</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; " class=""> </div>

Could This App Treat Depression? | Popular Science

A new company with a Harvard psychiatrist as inventor-in-residence says it's got the research to back up its claims. BrainTracer Game Pr...