Can They Patent Your Genes? by Daniel J. Kevles | The New York Review of Books

<div></div><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 18px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">Can genes be patented? This spring, the Supreme Court will hear a case that may well decide the question, and the consequences for American biomedicine could be huge.<sup id="fnr-1"><a href="http://www.nybooks.com/articles/archives/2013/mar/07/can-they-patent-your-genes/?pagination=false#fn-1" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 3px; padding-right: 3px; padding-bottom: 3px; padding-left: 3px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; text-decoration: underline; ">1</a></sup> Over three years ago, in May 2009, the American Civil Liberties Union (<acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">ACLU</acronym>) and the Public Patent Foundation (<acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">PPF</acronym>) filed a lawsuit in the Federal District Court for the Southern District of New York seeking to overturn the patents on <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">DNA</acronym> isolated from two human genes.<sup id="fnr-2"><a href="http://www.nybooks.com/articles/archives/2013/mar/07/can-they-patent-your-genes/?pagination=false#fn-2" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 3px; padding-right: 3px; padding-bottom: 3px; padding-left: 3px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; text-decoration: underline; ">2</a></sup> Called <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">BRCA</acronym>1 and <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">BRCA</acronym>2, the genes significantly increase a woman's risk of breast and ovarian cancer. The main defendant was the Myriad Genetics Corporation, a biotechnology firm in Utah that controls the patents—and is legally entitled for the life of the patent (now twenty years) to exclude all others from using these genes in breast cancer research, diagnostics, and treatment. Other defendants were the University of Utah Research Foundation, which had come to own the patents, and the United States Patent and Trademark Office (<acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">PTO</acronym>), which had granted them.</p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 18px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">The plaintiffs were not the usual parties in patent suits: competitors concerned with their balance sheets. They included medical geneticists, pathologists, and advocates for women's health, as well as biomedical researchers, genetic counselors, and several women with breast cancer or at risk for it. They were distressed that Myriad's patents allowed it to exercise such monopolistic control over a biological substance as essential to research, medicine, and patients as <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">DNA</acronym> implicated in cancer. They contended that <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">BRCA</acronym> <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">DNA</acronym>—and by implication all human <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">DNA</acronym>—should not be eligible for patents as a matter of law and that Myriad's enforcement of its patents interfered with the progress of science and the delivery of medical services.</p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 18px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">The plaintiffs had the support, expressed in friend-of-the-court briefs, of many parties representing the medical profession, biomedical researchers, and patients, all opponents of allowing anyone monopoly rights on human <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">DNA</acronym>. The Myriad Genetics Corporation, however, had many allies from the biotechnology industry, patent lawyers, and various genomic companies—all of whom said the grant of such rights was needed for their business. In American law, opponents of a public policy cannot ordinarily pursue their objections in the federal courts, including in patent suits, unless the policy causes an injury that gives them standing to sue.<sup id="fnr-3"><a href="http://www.nybooks.com/articles/archives/2013/mar/07/can-they-patent-your-genes/?pagination=false#fn-3" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 3px; padding-right: 3px; padding-bottom: 3px; padding-left: 3px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; text-decoration: underline; ">3</a></sup>The plaintiffs contended that they had suffered harms, offering in evidence how Myriad enforced its <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">BRCA</acronym> patents—in the clinic and the laboratory—to stop others from using the genes to do research on cancer. On November 2, 2009, over the objections of Myriad and the <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">PTO</acronym>, Judge Robert W. Sweet, the presiding judge, granted all the plaintiffs standing to sue Myriad, holding that, given the gravity of the issue for health and science, they had every right to call Myriad, the <acronym style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">PTO</acronym>, and gene patents to account.</p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 18px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-style: initial; border-color: initial; font-weight: inherit; font-style: inherit; vertical-align: baseline; ">More ...</p><div><span class="Apple-style-span" style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><a href="http://www.nybooks.com/articles/archives/2013/mar/07/can-they-patent-your-genes/?pagination=false">http://www.nybooks.com/articles/archives/2013/mar/07/can-they-patent-your-genes/?pagination=false</a></span><br></div>

Can They Patent Your Genes? by Daniel J. Kevles | The New York Review of Books

Can genes be patented? This spring, the Supreme Court will hear a case that may well decide the question, and the consequences for American ...

Read more »

It's President's Day, Hail to the Chef!!

<div dir="ltr" style="text-align: left;" trbidi="on"><div dir="ltr" style="text-align: left;" trbidi="on">What better way to laud our Presidents than to create an Executive Office restaurant with a full menu of culinary delights in their honor?<br /><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhxIegcDk-_wpbbBf8Tjp3aRT1rZjA-tj_hjJM8H7YqK7_I6rgfjmxT4rxbSzzHKP3QYlsI2TKI7BowW4hoivImLfy27Fg-FK9lDI9ce5WqArAlt_56ETii3QYJBeOLqdS-a_eM-3hoQM8/s1600/Club+Sandwich.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="306" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhxIegcDk-_wpbbBf8Tjp3aRT1rZjA-tj_hjJM8H7YqK7_I6rgfjmxT4rxbSzzHKP3QYlsI2TKI7BowW4hoivImLfy27Fg-FK9lDI9ce5WqArAlt_56ETii3QYJBeOLqdS-a_eM-3hoQM8/s400/Club+Sandwich.jpg" width="400" /></a><br />So to wit, and heretofore…<br /><br />Welcome to the best eatery anywhere…<i>Air Force Yum.</i><br /><br />Ready for breakfast? How about trying an <i>Abra-Ham and Cheese Omelet</i>? Instead of eating it along with boring slices of toast, try our <i>Mary Todd Lincoln Crazy Bread</i>.<br /><br />If you phone ahead, you can even reserve the coveted John Wilkes booth.<br /><br />Eggs not your first choice? Perhaps you are more of a pancake and sausage kind of person, and prefer JFK to Honest Abe. No problem...<br /><br />Order a plate full of our <i>Bay of Pigs in a Blanket</i>. The cakes are fluffy and the sausage has a hint of Cuban spices. Bueno!!<br /><br />You can always stop by for lunch as well.<br /><br />If you like a good hamburger try our <i>Cow-Vin Coolidge Burger</i>. We cook the beef until well done so the meat doesn't make a sound. Silent Cal would have it no other way.<br /><br />A well made Club Sandwich is increasingly hard to find, but not at our place. We use three layers of the best turkey, ham, roast beef, and the freshest tomato and lettuce in ours.<br /><br />This is a giant sandwich inspired by a giant in American Politics, Franklin Roosevelt.<br /><br />Order this, and the only thing your hunger will fear will be the deliciousness of our <i>Cripple-Decker Club</i>.<br /><br /><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4AaMXo6U50o6vUnUo6_TYpSxYbQFEtn0_6YuGBzax8InYdB4E1ptJsWOP6zJkps10XZTQyE2Gzw3duQKzwKcy0HzkSvhyvwQc2YAWQmKV09oCII-x_79UWtE9oCZUjPKy8j-38VpCcWY/s1600/Chris+Christie+2016.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="299" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4AaMXo6U50o6vUnUo6_TYpSxYbQFEtn0_6YuGBzax8InYdB4E1ptJsWOP6zJkps10XZTQyE2Gzw3duQKzwKcy0HzkSvhyvwQc2YAWQmKV09oCII-x_79UWtE9oCZUjPKy8j-38VpCcWY/s320/Chris+Christie+2016.jpg" width="320" /></a>Maybe you’d like to nosh on a few appetizers. We got ’em. Try our Teddy Roosevelt inspired, <i>Speak Softly and Carry a Big Fried Cheese Stick</i>.<br /><br />Another popular snack is our <i>William McKinley Buffalo Wings</i>. They are to die for.<br /><br />Another appetizer was recently added in speculative honor of the man who may be elected President in 2016.  We are now offering deep-fried whale nuggets.  So ahoy and climb aboard, as you delight in our new, <i>Crisp Christie Bites</i>.<br /><br />We have plenty of dinner entrees from which to choose as well. One popular dish is our <i>Chester A. Arthur Mutton Chops</i>. These mutton chops are big and delicious just like Chester’s…minus the hair.<br /><br />Not a glutton for mutton?<br /><br />A rising star on our dinner menu is the other white meat in the form of our uber-juicy <i>James K. Polk Chops</i>.<br /><br />These chops are butterflied and stuffed with spinach, bleu cheese, and seasoned with copious amounts of obscurity. Who knew that our eleventh President tasted so good!?<br /><br />We also offer tribute to former White House Wizard, George W. Bush. For a big, Texas-Sized appetite try our <i>Iraq of Lamb</i>. Upon trying this dish, President Bush said, <i>“Dang, these is some good.”</i><br /><br />We offer some great Italian fare too. Start off with our <i>Benjaminestrone Harrison</i> soup, followed by a <i>James A. Garfield of Arugula</i> salad, and top your repast off with our award winning <i>Harry Trumanicotti.</i><br /><br />Are you more a fan of seafood and Obama? We've got you covered. Try either our <i>Oysters Barackerfeller </i>or our <i>Deep Fried Mishellfish Platter</i>.<br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhUYjb7y6fTOvGnojscDFlGLp4KBLscD7nA8rGthFxxyIWTAaxUlai8GuLAvmU9xSBRZpQpHPJjVcLkzYHQrZ_hyML4NVJwBWsewzyrx_ouvJJRr2W6RNB1pK5PptRWcLBiPR2pJpD55Vw/s1600/James+Buchanan+Gay.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="287" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhUYjb7y6fTOvGnojscDFlGLp4KBLscD7nA8rGthFxxyIWTAaxUlai8GuLAvmU9xSBRZpQpHPJjVcLkzYHQrZ_hyML4NVJwBWsewzyrx_ouvJJRr2W6RNB1pK5PptRWcLBiPR2pJpD55Vw/s320/James+Buchanan+Gay.jpg" width="320" /></a></div><br />Ready for dessert?  Delight in our <i>Andrew Johnson Impeachment Cobbler</i>, <i>Sherbet Hoover</i>, or even our world renown<i> Hasty</i> <i>Tasty Pasty Cakes</i> in honor of our only gay President, James Buchanan.<br /><br />Well there you have it, a menu fit for a President. And don't forget...<br /><br />If you like the food here and want to come back again and again, sign up for huge discounts by purchasing our <i>William H. Taft Frequent Diner Card</i>.  And folks…<br /><br />Celebrate President’s Day by having a cocktail at Air Force Yum, as well.<br /><br />We mix blue vodka, a splash of sweet Vermouth, a dram of Manischewitz, a shot of ego, and voila…<br /><br />Mmmmm...I love a good <i>Bill Clintini</i> in the morning. Happy Presidents Day!!<br /><br />Cheers!!<br /><br />Matt-Man<br /><a href="mailto:mattmaniws@ymail.com">mattmaniws@ymail.com</a><br /><a href="https://twitter.com/MattMan_IWS" target="_blank">@mattman_iws</a><br />.<br /><br /></div></div>

It's President's Day, Hail to the Chef!!

What better way to laud our Presidents than to create an Executive Office restaurant with a full menu of culinary delights in their honor? S...

Read more »

Clean Well

<div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEioCvx0DtkFMx3bzfZNJ509B4QbrvvwmtmHzwFKcdke4vRuWn7pGqb3Uw2SE4qvbXvhEA6xLLhIBgtMUoVxRM0T2kS54ZmAh2uGXJKQX0PzhSrWsnICwfUXCLXaInkX5fyYPVzyFDtNyoE/s1600/cleanwell_logo.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEioCvx0DtkFMx3bzfZNJ509B4QbrvvwmtmHzwFKcdke4vRuWn7pGqb3Uw2SE4qvbXvhEA6xLLhIBgtMUoVxRM0T2kS54ZmAh2uGXJKQX0PzhSrWsnICwfUXCLXaInkX5fyYPVzyFDtNyoE/s1600/cleanwell_logo.png" /></a></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">That's right, flu season has arrived.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Ugh, no fun at all when there are tons of icky germs going around in and out of the school systems.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">How do you keep yourself and loved ones from getting sick in your home?</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I keep myself from getting sick by constantly washing my hands.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">With that in mind though my hands get very dry and cracked and irritated. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I look for the best products such as hand soaps, sprays, or lotions etc. for my hands. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">One that will moisturize my skin to keep from drying out.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">With winter here it just zaps the moisture right out! </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">poof!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgNaoTz5A46cS3PJi60fGogBSDiC-iMkf8wTcWvpfInmTHNwTThgKSLKuzJ_URmpBDJ4pQEuix0xJLi1SrUVHePK25gt_LPJCnLuKI7NTE9Ga_O6nJeekgVNjYeRlYi3yuNcgVcjQzMEuk/s1600/orange+vanilla.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgNaoTz5A46cS3PJi60fGogBSDiC-iMkf8wTcWvpfInmTHNwTThgKSLKuzJ_URmpBDJ4pQEuix0xJLi1SrUVHePK25gt_LPJCnLuKI7NTE9Ga_O6nJeekgVNjYeRlYi3yuNcgVcjQzMEuk/s320/orange+vanilla.jpg" width="320" /></a></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">The wipes packet is missing from the picture above, used them all. oops. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">When I found out I was going to do a review for <a href="http://www.cleanwelltoday.com/our-products/hand-sanitizer/">Clean Well</a> hand products I was ecstatic!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Was even more happy when I found out I was going to be receiving EOS hand lotion and lip balms with my Clean Well products to review.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I hate to complain, because I love these products.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">They work great and are keeping my hands from drying out.</span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Well when my package arrived I didn't receive the EOS products.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Instead I received sample sizes of the products for Clean Well, which is great!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">So I then emailed the person who sent them to me and told him that I didn't receive the EOS products.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Don't get me wrong,</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I have to say I loved using them!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><u>Facts:</u></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">all natural</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">alcohol free</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">safe for kids</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">4 times more uses out of it than gels</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">moisturizing formula so you won't dry out your hands</span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><u>Orange Vanilla spray:</u></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Don't have time to wash your hands?</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Spritz some Orange Vanilla and voila clean hands!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I love how when you spray it on you don't get the alcohol smell like other products have such as gels for hands. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Instead you get the sweet and delicious aroma of orange vanilla.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><u>Botanical Wipes:</u></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Smells wonderful and cleans hands on contact.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">All you have to do is just wipe your hands and your good to go!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I love them so much that I even use them as a disinfecting wipe for furniture! </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">EOS hand lotion:</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">makes my hands feel soft and look renewed.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Also smells great!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">no more dryness!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Now I know the kind of lotion that works for me!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">EOS lip balms:</span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">hello hydration, makes them kiss-ably smooth.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><u>other products they sell:</u></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">hand and face wipes</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">foaming soap</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">liquid soap</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">fabric deodorizers </span></div><div style="text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjioD4dgflQiDv3Zz1HWkEl0oHKfqqxED_ZZwQfxOJ-wrosBrnFwsZUVB722tP04Ne5R57mOzD66cnbqlEJbLb6Dc9jpWaAI_EJet8VPBwpsJxx53kszMKKR_oOKJBrAcI56WFUTKWtKI/s1600/cleanwell+package.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjioD4dgflQiDv3Zz1HWkEl0oHKfqqxED_ZZwQfxOJ-wrosBrnFwsZUVB722tP04Ne5R57mOzD66cnbqlEJbLb6Dc9jpWaAI_EJet8VPBwpsJxx53kszMKKR_oOKJBrAcI56WFUTKWtKI/s320/cleanwell+package.jpg" width="320" /></a></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">After I emailed, I received a response then was shocked when I received this!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Yes, I received the EOS products, but when the package arrived it was ripped and the containers of the wipes were busted and smashed. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">You can see in the below photos.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">One of the bottles was smashed beyond repair by having the top of it cracked where the wipes were exposed.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">So glad they didn't dry out though because I put them in a zip lock baggie. </span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgdk4OFSptekI8PdMLqTmJ7ot2KuLb_I_ylgwkhPnQ7KueyuLMTC_7Ybny4X0fNxm7HSA3cKM-MOqvOsGSQwcgWYJn24xfCBVsegXSPNMfd56gmlAy3mnUCULOhL17YhiigD1ibVzzMAYo/s1600/cleanwell.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgdk4OFSptekI8PdMLqTmJ7ot2KuLb_I_ylgwkhPnQ7KueyuLMTC_7Ybny4X0fNxm7HSA3cKM-MOqvOsGSQwcgWYJn24xfCBVsegXSPNMfd56gmlAy3mnUCULOhL17YhiigD1ibVzzMAYo/s320/cleanwell.jpg" width="320" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">After I had saw the damage I emailed and haven't heard a response since. </span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Like I stated earlier though I love the products and couldn't be more happier that my hands are no longer very dry.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">I was just not too thrilled how this package above was shipped to me.</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Other than that they work great, smell great and leave your hands feeling clean!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Want to check out their products?</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Check them out online here!</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><a href="https://www.facebook.com/cleanwell">https://www.facebook.com/cleanwell</a></span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><a href="https://twitter.com/cleanwell">https://twitter.com/cleanwell</a></span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><a href="http://pinterest.com/cleanwell/">http://pinterest.com/cleanwell/</a></span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Sold at:</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Whole Foods</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Kroger</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Earht fare</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">The Vitamin Shoppe</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">GNC</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">Stop & Shop</span></div><div class="separator" style="clear: both; text-align: center;"><span style="font-family: Verdana, sans-serif;">and much more! </span></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div style="text-align: center;"><br /></div>

Clean Well

That's right, flu season has arrived. Ugh, no fun at all when there are tons of icky germs going around in and out of the school systems...

Read more »

DNA Patches Will Simplify Vaccines - Business Insider

<base href="data:"><div style="font-family: Helvetica; color: black; text-align: left; "><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">An innovative new way to deliver vaccines could drastically improve the health of the third world, and even the first world, by making vaccines cheaper and easier to distribute and use. The "vaccine patch" would be as easy to apply as a Band-Aid, and would be stable for weeks at room temperature.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"You could potentially get a vaccine patch over the counter from your pharmacist, go home, and wear it for a couple minutes, then pull it off, and that's your vaccine," <a href="http://www.linkedin.com/pub/peter-demuth/5b/282/134" style="text-decoration: none; color: rgb(29, 99, 125); ">researcher Peter DeMuth</a> told <a class="hidden_link" href="http://www.businessinsider.com/blackboard/business-insider" style="text-decoration: none; color: rgb(29, 99, 125); ">Business Insider</a>.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The patch differs from the nicotine and birth control patches currently in use. It uses tiny "microneedles" coated in DNA, which is deposited into the very outer layer of the skin. The needles are so small they are painless, they don't pierce down to the level of blood vessels so there's no bleeding, and no risk of infection.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"What we've shown in the paper is that we can make these coatings in the right way we can apply the microneedle to the skin of the patient, for only 10 to 15 minutes, and then remove the needles and those coatings will be deposited into the skin," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">Acquiring immunity</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Multiple groups are working to design these microneedle vaccination patches. The most recent work was published in <a href="http://www.nature.com/nmat/journal/vaop/ncurrent/nmat3550/metrics/blogs" style="text-decoration: none; color: rgb(29, 99, 125); ">Jan. 27 in Nature Materials</a>, and came from DeMuth, a graduate student at M.I.T in the lab of Darrell Irvine.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">DNA vaccines work by inserting strands of DNA, the molecule that holds the instructions that keep our bodies working, into the body's cells. The DNA holds the code for a protein — a protein from a virus or bacteria, for example — which the body senses is foreign.  </p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"We just deliver the DNA and allow the cells of your body, the patient's body, to produce those for us," DeMuth said.</p><div class="image-container float_right" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; width: 620px; "><div class="image" style="margin: 0px; padding: 0px; "><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_DO9u0lYD9K90FZMwRWm5LmdXSULkC3JPx7sZMERwOB15zhM_69YDR9ijZViZl7UNBvSDBDaFqmVUDbMbfn91GwU4HqEscKpFAjhNf8mxTJQ7iZ69Y1tKqR-c_ZkmFnrZGeMrF24hGw4/s1600/screen+shot+2013-01-25+at+12.39.53+pm-752081.png"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5846042130950275874" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_DO9u0lYD9K90FZMwRWm5LmdXSULkC3JPx7sZMERwOB15zhM_69YDR9ijZViZl7UNBvSDBDaFqmVUDbMbfn91GwU4HqEscKpFAjhNf8mxTJQ7iZ69Y1tKqR-c_ZkmFnrZGeMrF24hGw4/s320/screen+shot+2013-01-25+at+12.39.53+pm-752081.png" /></a></div><p class="source" style="margin: 1em 0px 0px; padding: 0px; "><a href="http://www.nature.com/nmat/journal/vaop/ncurrent/nmat3550/metrics/blogs" style="text-decoration: none; color: rgb(29, 99, 125); ">DeMuth, et. al, Nat. Met., 2013</a></p><p class="caption" style="margin: 1em 0px 0px; padding: 0px; ">The tiny needles are coated with vaccine, which they deposit into the outer layers of the skin.</p></div><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The body mounts an immune defense to this foreign protein, and this response is what protects us from that disease when it tries to invade us and sicken us — the immune system recognizes the foreign protein and is able to vanquish the invading virus or bacteria before it gets a foothold in the body.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Though they worked in small animals in the lab, previous attempts to make DNA vaccines failed when they reached monkey trials, but those vaccines were injected into the muscles, which isn't the ideal place to mount an immune defense. In theory DNA vaccines worked, but it seemed as if the idea had hit an impasse.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">A new approach</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">To make DNA vaccines work, researchers had to go back to the drawing board and think up new ways to administer the DNA.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"DNA vaccines could make a big difference in the way we immunize people, but we are still kind of stuck at this place where it's difficult to get human cells to take up DNA and express it as proteins in the same ways that small animal models do, " DeMuth said.</p><div><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">For the study, they tested a new way of applying vaccine — coating microneedles in DNA and having them pierce the outer layer of the skin, depositing the DNA package inside. They made these microneedles, which are half a millimeter long, into patches and checked out how effective they were in mice and monkeys.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The needles can be coated in different layers which would change the way the vaccine is released into the skin — faster or slower, or even in a certain sequence.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">They tested mice and monkeys with a centimeter-wide circle of microneedles, applied directly to the skin. The skin is where our body is fighting off infections every day, so it's full of disease fighting white blood cells that are primed to react to these foreign proteins. They saw this skin-based application really worked to improve the body's reaction to the DNA vaccination.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">For the test, the needles were coated with the DNA that encodes a glowing protein from fireflies. If the DNA got into the animal's cells and was expressed, then the skin should glow, which it did.</p><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">Then they had to check to see if the cells were making proteins that got into the blood and activated the immune system, which they checked using a protein from the monkey version of HIV, the virus that causes AIDS. They then checked the animal's blood for evidence that it had reacted to the proteins, recognizing them as foreign, which they had.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"The good news is that all the studies up to now, in mice and in primates, have looked very promising, so the next step would be to verify this more robustly in primates," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">There's still a lot of work left to do to get the patch working in humans and through clinical trials, but when approved, the patch vaccine will have plenty of advantages.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">A major improvement</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">First, DNA is easier to make in large quantities than proteins are. </p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Secondly, once created, the patches don't need to be refrigerated — they survive just fine for weeks on end at room temperature. This makes them easier and cheaper to transport and administer, especially in third-world countries where refrigeration is expensive and needles are incredibly dangerous.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"DNA has the advantage that it could be potentially more stable for transportation for distribution throughout the world as a vaccine," DeMuth said. That would drastically diminish the costs of immunizing against disease in third-world countries.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"Those are the places you want vaccines to go and we need to find a way to eliminate that necessity for refrigeration if we are going to vaccinate those people who are most at risk," DeMuth said.</p><div><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">Third, the patches would remove the need for needles for application of vaccines. Needles spread disease because they are reused, are expensive, and require training to use. Needle puncture wounds can also get infected. Because the patch doesn't breach the outer layers of the skin, it never reaches the blood vessels and would be much less likely to become infected.</span><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Also, using a DNA vaccine is much safer than vaccinating with a dead or mutated virus, as most traditional vaccines do. These could contain small amounts of live or healthy virus or bacteria that could cause infections.</div><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"For example, HIV is a virus, and the risk is if you would give that virus to a patient in a vaccine form, even if it is weakened, there is still the potential that you could actually cause infection as opposed to just eliciting the immunity you are looking for," DeMuth told us.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">Flexible technology</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Another great thing about DNA vaccines? They can be made for almost any thing, including many of the diseases we already have vaccines for.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">DNA can be made that can create any protein — be it part of a virus, a bacteria, fungus, or even tumor cells. Just about any current vaccine could be changed into a DNA patch vaccine.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"Every vaccine, for the most part, is centered around proteins and every protein can be generated from a piece of DNA," DeMuth said. "DNA is a starting place for everything that we would want to immunize against."</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The patch technology isn't just for viruses and bacteria though, several researchers are also developing "vaccines" for things like cancer. These would train the body to recognize tumor cells by the kinds of proteins they made (some of which are different from the proteins in our normal body cells).</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"You can even develop a DNA vaccine that encoded a piece of protein that distinguishes tumor cells from self or healthy cells, and you could use that to immunize against cancer," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">As the technology improves, we should start seeing microneedle patch vaccines in human trials in about a decade.</p><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><br></span></div><a href="http://www.businessinsider.com/in-the-future-preventing-infectious-diseases-could-be-as-easy-as-applying-a-bandaid-2013-2">http://www.businessinsider.com/in-the-future-preventing-infectious-diseases-could-be-as-easy-as-applying-a-bandaid-2013-2</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><br class="webkit-block-placeholder"></div>

DNA Patches Will Simplify Vaccines - Business Insider

An innovative new way to deliver vaccines could drastically improve the health of the third world, and even the first world, by making vacci...

Read more »

Teach This! Teaching with lesson plans and ideas that rock 02/17/2013

<ul class="diigo-linkroll"> <li> <p class="diigo-link"> <a href="http://www.squidoo.com/adobe-photoshop-lightroom-2">Totally Free Commercial Use Images ✔ The Ultimate Photo Resource Guide</a> </p> <p class="diigo-description">As students work on projects, permissions for photos is important, this website lists 50 of the top places to get free photos.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/photography">photography</a> <a href="https://www.diigo.com/user/coolcatteacher/digital">digital</a> <a href="https://www.diigo.com/user/coolcatteacher/citizenship">citizenship</a> <a href="https://www.diigo.com/user/coolcatteacher/permissions">permissions</a> <a href="https://www.diigo.com/user/coolcatteacher/digital_responsibilities">digital_responsibilities</a></p> </li> <li> <p class="diigo-link"> <a href="http://voices.yahoo.com/digital-photography-lessons-high-school-classes-11779016.html">Digital Photography Lessons for High School Classes - Yahoo! Voices - voices.yahoo.com</a> </p> <p class="diigo-description">Some interesting lessons for teaching photography with students in high school classes. I like to use photos on flickr as we discuss the rule of thirds, and other techniques. </p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/photography">photography</a> <a href="https://www.diigo.com/user/coolcatteacher/technology">technology</a></p> </li> <li> <p class="diigo-link"> <a href="http://www.guide2digitallearning.com/teaching_learning/10_ways_use_avatars_education">10 Ways To Use Avatars In Education | Digital Learning Environments</a> </p> <p class="diigo-description">If you can't use photos, avatars are a great replacement. Here are some suggestions for how to use avatars.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/education">education</a> <a href="https://www.diigo.com/user/coolcatteacher/avatars">avatars</a> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/digital">digital</a> <a href="https://www.diigo.com/user/coolcatteacher/citizenship">citizenship</a></p> </li> <li> <p class="diigo-link"> <a href="http://school.discoveryeducation.com/schooladventures/slavery/">Understanding Slavery - Learning Adventures</a> </p> <p class="diigo-description">Discovery Education has a set of resources covering this topic that will have some things you can use as part of Black History Month including teacher tips and resources.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/blackhistory">blackhistory</a> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/sschat">sschat</a> <a href="https://www.diigo.com/user/coolcatteacher/tumblr">tumblr</a></p> </li> </ul><p class="diigo-ps">Posted from <a href='https://www.diigo.com'>Diigo</a>. The rest of my favorite links are <a href='https://www.diigo.com/user/coolcatteacher'>here</a>.</p>

Teach This! Teaching with lesson plans and ideas that rock 02/17/2013

Totally Free Commercial Use Images ✔ The Ultimate Photo Resource Guide As students work on projects,...

Read more »

'SNL' Scorecard: Christoph Waltz Hosts The Best Show Of The Season

<div dir="ltr" style="text-align: left;" trbidi="on"><span style="background-color: white; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px;">  </span><img alt="christoph waltz snl" src="http://i.huffpost.com/gen/995641/original.jpg" style="background-color: white; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px;" /><br /><br /><div class="float_left" style="background-color: white; border: none; float: left; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px; list-style: none; margin: 0px; padding: 0px;"><a href="http://www.huffingtonpost.com/mike-ryan" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;"><img alt="Mike Ryan" height="45" src="http://s.huffpost.com/contributors/mike-ryan/headshot.jpg" style="border: none; float: left; list-style: none; margin: 0px; padding: 0px; text-align: center; vertical-align: baseline;" width="45" /></a></div><div class="float_left fixed_width_author" style="background-color: white; border: none; float: left; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px; list-style: none; margin: 0px; padding: 0px; width: 195px;"><h2 style="border: none; float: left; list-style: none; margin: 0px 0px 0px 8px; padding: 0px;"><a href="http://www.huffingtonpost.com/mike-ryan" rel="author" style="border: none; color: #760101; cursor: pointer; font-family: Arial, Century, Times, serif !important; font-size: 20px !important; height: inherit; letter-spacing: 0.05em; line-height: 24px !important; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;">Mike Ryan</a></h2><div class="teaser_permalink" style="border: none; clear: both; float: left; font-size: 11px !important; font-style: italic !important; line-height: 11px !important; list-style: none; margin-bottom: 4px !important; margin-left: 7px !important; margin-top: 4px !important; padding: 0px; width: 180px;">Senior Entertainment Writer, The Huffington Post</div><div class="teaser_permalink" style="border: none; clear: both; float: left; font-size: 11px !important; font-style: italic !important; line-height: 11px !important; list-style: none; margin-bottom: 4px !important; margin-left: 7px !important; margin-top: 4px !important; padding: 0px; width: 180px;"></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;">oK, yes, I have calmed down from last week's disaster of a show. Order has been restored. Not only did an actual <i style="border: none; list-style: none; margin: 0px; padding: 0px;">actor</i> host "SNL" this week -- after back-to-back shows featuring musical artists as the host -- an <i style="border: none; list-style: none; margin: 0px; padding: 0px;">Academy Award-winning</i> actor hosted. Oh, and, strangely, there was not one sketch in which Christoph Waltz played himself, like we have seen, lazily, with the hosts as of late. (Though, Waltz did play both the pope <i style="border: none; list-style: none; margin: 0px; padding: 0px;">and</i> Jesus.) Enough with the negative! Waltz was fantastic, which resulted in the best show of the season. Waltz is the type of actor who can do almost anything and it felt like there was a lot of saved up material, just waiting for a host that could do almost anything. On to a rejuvenated Scorecard!</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;"><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">Sketch(s) of the Night</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"What Have You Become Game Show"</strong> (Christoph Waltz, Kenan Thompson, Bill Hader, Aidy Bryant) Along with the cold open, this was the second time that Alabama got a mention tonight. Admittedly, I was worried when I saw this was a game show sketch. Yes, there have been great game show sketches over the years, but "SNL" has a tendency to sleepwalk through these types of things, too. Instead, the format is turned on its ear as each formerly happy contestant is asked what he or she had done with his or her individual life. The best part was the depressing theme music that played as each contestant, then host, gave their answers. "What Have You Become Game Show" is one of the best sketches of this season.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=b9ib1h9yewagz-3ashl91w&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score 9.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"New Tarantino Movie"</strong> (Christoph Waltz, Taran Killam, Jay Pharoah) A fake movie trailer for the new Tarantino revenge film, "Djesus Uncrossed," with blurbs from critics that include, "I never knew how much Jesus used the n-word" and dialogue like "The H is silent." Honestly, I can't remember the last time I debated this much over sketch of the night. So, screw it, it's my scorecard and if I want two sketches of the night, there can be two sketches of the night. It was just <strong style="border: none; list-style: none; margin: 0px; padding: 0px;">that</strong> solid of a show. (And I always love Killam's Brad Pitt.) Honestly, for a lot of reasons, I can't believe this even aired. It's nice to see "SNL" test the limits.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=c58yzofllrerzs1t6cvz7a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score 9.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Good</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Retirement Ad"</strong> (Christoph Waltz, Jason Sudeikis) Remember a few weeks ago when "SNL" aired the commercial parody for the home Starbucks machine -- and the gist was that the machine would get the owners name wrong ... then the sketch just kept going <i style="border: none; list-style: none; margin: 0px; padding: 0px;">and going</i> for no apparent reason? The joke was over. I was reminded of that while watching this because the Pope's retirement could have <i style="border: none; list-style: none; margin: 0px; padding: 0px;">easily</i> been a one-note joke, too. Yet, here, it was made into a retirement firm narrative that<i style="border: none; list-style: none; margin: 0px; padding: 0px;">ended</i> with the best joke about no other testimonials available.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=sifch4v12z8wwg58vyebwg&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 8.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Weekend Update"</strong> (Seth Meyers, Taran Killam, Kate McKinnon, Jay Pharoah) It's interesting, because it was evident on Seth Meyer's face that he knew that "SNL" was having a good night. And, thankfully, "Update" came out strong, too, with <i style="border: none; list-style: none; margin: 0px; padding: 0px;">three</i> segments. I have no idea what the crossover audience is for "SNL" and people who know who Stephen A. Smith is, but, boy, Pharoah's Stephen A. Smith is pretty fantastic. Also, I've <i style="border: none; list-style: none; margin: 0px; padding: 0px;">never</i> seen Pharoah break character, but if he didn't <em style="border: none; list-style: none; margin: 0px; padding: 0px;">fully</em> break last night, he came <i style="border: none; list-style: none; margin: 0px; padding: 0px;">really</i> close. Kate McKinnon and Seth Meyers seemed to be having the time of their lives with her "person who saw the Russian meteor" character. And it looks like Taran Killam will be taking on the role of Marco Rubio (good grief, I hope Killam's "parched Rubio voice" remains part of the impression forever), which <i style="border: none; list-style: none; margin: 0px; padding: 0px;">might</i> be tough once the Republican primaries start, considering he also plays Paul Ryan.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=ea2jyee9yr9ogiz9-boy1a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.8</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Jamarcus Brothers"</strong> (Christoph Waltz, Taran Killan, Cecily Strong, Kenan Thompson, Jay Pharoah) I wish the Jamarcus Brothers would have played "Where does my penis go, point to where" during this sketch. You know, with a lesser host, this could have been ... not great. But the chemistry between Pharoah and Thompson, with Waltz as their oddball third brother of the musical trio, wound up hitting.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=p2gcjjzqlnq38ogx1erfja&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.4</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Cold Open: Cruise Ship"</strong> (Jason Sudeikis, Cecily Strong, Jay Pharoah, Tim Robinson, Bobby Moynihan, Fred Armisen) This is perhaps the most depressing sketch "SNL" has ever aired. Not that it wasn't funny, but, <i style="border: none; list-style: none; margin: 0px; padding: 0px;">boy</i> this has been a lousy week as far as news goes -- which this sketch keenly reminded us. In other words: Instead of being a one-note sketch about the Poop Cruise, it was used as a way to address most of the recent (depressing) news items of the week. And it was nice seeing Cecily Strong playing a character that doesn't have some sort of "funny voice." Also, even though his monkey was eaten, I hope this isn't the last time we see Moynihan's Dan the Animal Man.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=0cwr2rq-jidcxlufelqrlg&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Secret Admirer Letter"</strong> (Christoph Waltz, Cecily Strong, Jason Sudeikis, Bill Hader, Kenan Thompson, Vanessa Bayer) It feels like it's been a few weeks since we had a truly bizarre 10 to 1 sketch. I'm not sure that "Secret Admirer Letter' qualifies as "bizarre," but you know what? Close enough. If nothing else, it featured a half naked Christoph Waltz leaning against a Ferrari.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=ovzmxbdndgni7sv5hy6nlq&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.6</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Christoph Waltz Monologue"</strong> (Christoph Waltz, Kate McKinnon, Bobby Moynihan, Taran Killam, Nasim Pedrad, Cecily Strong, Fred Armisen) Wow, I never thought I'd ever laugh at something called "Casual Hitler." This was a fairly good monologue because it showed that Waltz came with a level of, well, talent for acting in front an audience that we hadn't seen in a few <i style="border: none; list-style: none; margin: 0px; padding: 0px;">long</i>weeks. And it was nice to see a good amount of the cast get involved, which was a sign of things to come for the entire evening.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=jnntb2bumyh8boj_1e0v_a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Tippy"</strong> (Nasim Pedrad, Christoph Waltz, Bobby Moynihan, Tim Robinson, Vanessa Bayer, Kate McKinnon, Kenan Thompson, Bobby Moynihan) Yes, Nasim Pedrad has played this type of "annoying, know-it-all" character before, but this is the first time that I can remember it not being a boy or a young child. Granted, perhaps it was the general good will from the quality of the rest of the show, but I laughed quite often during "Tippy." And, yes, it was <em style="border: none; list-style: none; margin: 0px; padding: 0px;">really</em> nice to see Pedrad be a major part of the show.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=tpxpadkl7pxmfkme76znra" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Bad</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Fox and Friends: 2013 State of the Union"</strong> (Taran Killam, Bobby Moynihan, Vanessa Bayer, Bill Hader, Fred Armisen) It was weird, I initially enjoyed last night's edition of "Fox and Friends" because I always enjoy "Fox and Friends." But I think my initial delight might have just been a result of the always great list of corrections. ("Zero Dark Thirty is not a diet soda.") Re-watching this morning, this was one of the weaker "Fox and Friends" installments -- which might be why it was relegated to the end of the show, as opposed to its usual spot in the cold open.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=gyo6l-gf6uf5y7b1alyoiq&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 5.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Ugly</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Regine"</strong> (Christoph Waltz, Fred Armisen, Bill Hader, Vanessa Bayer, Aidy Bryant, Tim Robinson, Taran Killam) Oh, Regine, we were having such a nice evening before you showed up. The sentence before this one is how both the other characters in the sketch felt and how the audience at home felt watching. I mean, look, compared to what aired in past weeks, Regine would have been borderline <i style="border: none; list-style: none; margin: 0px; padding: 0px;">fine</i>. But our standards are just a little higher for this particular show and getting a glimpse of Fred Armisen's scrotum doesn't quite cut it this week.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe br="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=vp6ehyz8cyp6dl33d2_cna&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 4.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Average Score for this Show: 7.03</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">· Christoph Waltz 7.03</strong><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-martin-short_b_2311527.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Martin Short</a> 6.28<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-christina-applegate_b_1964996.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Christina Applegate</a> 6.13<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-seth-macfarlane_b_1887952.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Seth MacFarlane</a> 5.93<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-louis-ck_b_2072353.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Louis C.K.</a> 5.92<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-anne-hathaway_b_2113837.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Anne Hathaway</a> 5.87<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-bruno-mars_b_1997270.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Bruno Mars</a> 5.81<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-adam-levine_b_2561689.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Adam Levine</a> 5.71<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-joseph-gordon-levitt_b_1907329.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Joseph Gordon-Levitt</a> 5.51<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jamie-foxx_b_2267347.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jamie Foxx</a> 5.43<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jeremy-renner_b_2154730.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jeremy Renner</a> 5.39<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jennifer-lawrence_b_2516152.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jennifer Lawrence</a> 5.38<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-daniel-craig_b_1946309.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Daniel Craig</a> 5.35<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-justin-bieber_b_2657680.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Justin Bieber</a> 5.23</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><em style="border: none; list-style: none; margin: 0px; padding: 0px;">Mike Ryan is senior writer for Huffington Post Entertainment. You can contact him <a href="http://twitter.com/mikeryan" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_blank">directly on Twitter.</a> Click below for this week's "SNL," Not Ready For Primetime Podcast featuring Mike Ryan and Hitfix's <a href="https://twitter.com/TVMcGee" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Ryan McGee.</a></em></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe height="240" scrolling="no" src="http://html5-player.libsyn.com/embed/episode/id/2221260/height/240/width/427/theme/legacy/direction/no/autoplay/no/autonext/no/thumbnail/yes/preload/no/no_addthis/no/" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" width="427"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin: 0px; padding: 0px;"></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin: 0px; padding: 0px;"></div><div class="clear full" style="border: none; clear: both; font-family: Georgia, Century, Times, serif; font-size: 1px; font-style: normal; height: 8px; line-height: 1px !important; list-style: none; margin: 0px; overflow: hidden !important; padding: 0px;"> </div></div></div>

'SNL' Scorecard: Christoph Waltz Hosts The Best Show Of The Season

   Mike Ryan Senior Entertainment Writer, The Huffington Post oK, yes, I have calmed down from last week's disaster of a show. Order has...

Read more »