DNA Patches Will Simplify Vaccines - Business Insider

<base href="data:"><div style="font-family: Helvetica; color: black; text-align: left; "><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">An innovative new way to deliver vaccines could drastically improve the health of the third world, and even the first world, by making vaccines cheaper and easier to distribute and use. The "vaccine patch" would be as easy to apply as a Band-Aid, and would be stable for weeks at room temperature.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"You could potentially get a vaccine patch over the counter from your pharmacist, go home, and wear it for a couple minutes, then pull it off, and that's your vaccine," <a href="http://www.linkedin.com/pub/peter-demuth/5b/282/134" style="text-decoration: none; color: rgb(29, 99, 125); ">researcher Peter DeMuth</a> told <a class="hidden_link" href="http://www.businessinsider.com/blackboard/business-insider" style="text-decoration: none; color: rgb(29, 99, 125); ">Business Insider</a>.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The patch differs from the nicotine and birth control patches currently in use. It uses tiny "microneedles" coated in DNA, which is deposited into the very outer layer of the skin. The needles are so small they are painless, they don't pierce down to the level of blood vessels so there's no bleeding, and no risk of infection.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"What we've shown in the paper is that we can make these coatings in the right way we can apply the microneedle to the skin of the patient, for only 10 to 15 minutes, and then remove the needles and those coatings will be deposited into the skin," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">Acquiring immunity</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Multiple groups are working to design these microneedle vaccination patches. The most recent work was published in <a href="http://www.nature.com/nmat/journal/vaop/ncurrent/nmat3550/metrics/blogs" style="text-decoration: none; color: rgb(29, 99, 125); ">Jan. 27 in Nature Materials</a>, and came from DeMuth, a graduate student at M.I.T in the lab of Darrell Irvine.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">DNA vaccines work by inserting strands of DNA, the molecule that holds the instructions that keep our bodies working, into the body's cells. The DNA holds the code for a protein — a protein from a virus or bacteria, for example — which the body senses is foreign.  </p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"We just deliver the DNA and allow the cells of your body, the patient's body, to produce those for us," DeMuth said.</p><div class="image-container float_right" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; width: 620px; "><div class="image" style="margin: 0px; padding: 0px; "><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_DO9u0lYD9K90FZMwRWm5LmdXSULkC3JPx7sZMERwOB15zhM_69YDR9ijZViZl7UNBvSDBDaFqmVUDbMbfn91GwU4HqEscKpFAjhNf8mxTJQ7iZ69Y1tKqR-c_ZkmFnrZGeMrF24hGw4/s1600/screen+shot+2013-01-25+at+12.39.53+pm-752081.png"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5846042130950275874" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_DO9u0lYD9K90FZMwRWm5LmdXSULkC3JPx7sZMERwOB15zhM_69YDR9ijZViZl7UNBvSDBDaFqmVUDbMbfn91GwU4HqEscKpFAjhNf8mxTJQ7iZ69Y1tKqR-c_ZkmFnrZGeMrF24hGw4/s320/screen+shot+2013-01-25+at+12.39.53+pm-752081.png" /></a></div><p class="source" style="margin: 1em 0px 0px; padding: 0px; "><a href="http://www.nature.com/nmat/journal/vaop/ncurrent/nmat3550/metrics/blogs" style="text-decoration: none; color: rgb(29, 99, 125); ">DeMuth, et. al, Nat. Met., 2013</a></p><p class="caption" style="margin: 1em 0px 0px; padding: 0px; ">The tiny needles are coated with vaccine, which they deposit into the outer layers of the skin.</p></div><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The body mounts an immune defense to this foreign protein, and this response is what protects us from that disease when it tries to invade us and sicken us — the immune system recognizes the foreign protein and is able to vanquish the invading virus or bacteria before it gets a foothold in the body.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Though they worked in small animals in the lab, previous attempts to make DNA vaccines failed when they reached monkey trials, but those vaccines were injected into the muscles, which isn't the ideal place to mount an immune defense. In theory DNA vaccines worked, but it seemed as if the idea had hit an impasse.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">A new approach</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">To make DNA vaccines work, researchers had to go back to the drawing board and think up new ways to administer the DNA.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"DNA vaccines could make a big difference in the way we immunize people, but we are still kind of stuck at this place where it's difficult to get human cells to take up DNA and express it as proteins in the same ways that small animal models do, " DeMuth said.</p><div><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">For the study, they tested a new way of applying vaccine — coating microneedles in DNA and having them pierce the outer layer of the skin, depositing the DNA package inside. They made these microneedles, which are half a millimeter long, into patches and checked out how effective they were in mice and monkeys.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The needles can be coated in different layers which would change the way the vaccine is released into the skin — faster or slower, or even in a certain sequence.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">They tested mice and monkeys with a centimeter-wide circle of microneedles, applied directly to the skin. The skin is where our body is fighting off infections every day, so it's full of disease fighting white blood cells that are primed to react to these foreign proteins. They saw this skin-based application really worked to improve the body's reaction to the DNA vaccination.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">For the test, the needles were coated with the DNA that encodes a glowing protein from fireflies. If the DNA got into the animal's cells and was expressed, then the skin should glow, which it did.</p><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">Then they had to check to see if the cells were making proteins that got into the blood and activated the immune system, which they checked using a protein from the monkey version of HIV, the virus that causes AIDS. They then checked the animal's blood for evidence that it had reacted to the proteins, recognizing them as foreign, which they had.</span><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"The good news is that all the studies up to now, in mice and in primates, have looked very promising, so the next step would be to verify this more robustly in primates," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">There's still a lot of work left to do to get the patch working in humans and through clinical trials, but when approved, the patch vaccine will have plenty of advantages.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">A major improvement</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">First, DNA is easier to make in large quantities than proteins are. </p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Secondly, once created, the patches don't need to be refrigerated — they survive just fine for weeks on end at room temperature. This makes them easier and cheaper to transport and administer, especially in third-world countries where refrigeration is expensive and needles are incredibly dangerous.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"DNA has the advantage that it could be potentially more stable for transportation for distribution throughout the world as a vaccine," DeMuth said. That would drastically diminish the costs of immunizing against disease in third-world countries.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"Those are the places you want vaccines to go and we need to find a way to eliminate that necessity for refrigeration if we are going to vaccinate those people who are most at risk," DeMuth said.</p><div><br></div><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); display: inline !important; float: none; ">Third, the patches would remove the need for needles for application of vaccines. Needles spread disease because they are reused, are expensive, and require training to use. Needle puncture wounds can also get infected. Because the patch doesn't breach the outer layers of the skin, it never reaches the blood vessels and would be much less likely to become infected.</span><div style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Also, using a DNA vaccine is much safer than vaccinating with a dead or mutated virus, as most traditional vaccines do. These could contain small amounts of live or healthy virus or bacteria that could cause infections.</div><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"For example, HIV is a virus, and the risk is if you would give that virus to a patient in a vaccine form, even if it is weakened, there is still the potential that you could actually cause infection as opposed to just eliciting the immunity you are looking for," DeMuth told us.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><strong style="font-style: inherit; font-weight: bold; ">Flexible technology</strong></p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">Another great thing about DNA vaccines? They can be made for almost any thing, including many of the diseases we already have vaccines for.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">DNA can be made that can create any protein — be it part of a virus, a bacteria, fungus, or even tumor cells. Just about any current vaccine could be changed into a DNA patch vaccine.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"Every vaccine, for the most part, is centered around proteins and every protein can be generated from a piece of DNA," DeMuth said. "DNA is a starting place for everything that we would want to immunize against."</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">The patch technology isn't just for viruses and bacteria though, several researchers are also developing "vaccines" for things like cancer. These would train the body to recognize tumor cells by the kinds of proteins they made (some of which are different from the proteins in our normal body cells).</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">"You can even develop a DNA vaccine that encoded a piece of protein that distinguishes tumor cells from self or healthy cells, and you could use that to immunize against cancer," DeMuth said.</p><p style="margin-top: 1em; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; ">As the technology improves, we should start seeing microneedle patch vaccines in human trials in about a decade.</p><span style="color: rgb(0, 0, 0); font-family: Helvetica, Arial, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 16px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><br></span></div><a href="http://www.businessinsider.com/in-the-future-preventing-infectious-diseases-could-be-as-easy-as-applying-a-bandaid-2013-2">http://www.businessinsider.com/in-the-future-preventing-infectious-diseases-could-be-as-easy-as-applying-a-bandaid-2013-2</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><br class="webkit-block-placeholder"></div>

DNA Patches Will Simplify Vaccines - Business Insider

An innovative new way to deliver vaccines could drastically improve the health of the third world, and even the first world, by making vacci...

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Teach This! Teaching with lesson plans and ideas that rock 02/17/2013

<ul class="diigo-linkroll"> <li> <p class="diigo-link"> <a href="http://www.squidoo.com/adobe-photoshop-lightroom-2">Totally Free Commercial Use Images ✔ The Ultimate Photo Resource Guide</a> </p> <p class="diigo-description">As students work on projects, permissions for photos is important, this website lists 50 of the top places to get free photos.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/photography">photography</a> <a href="https://www.diigo.com/user/coolcatteacher/digital">digital</a> <a href="https://www.diigo.com/user/coolcatteacher/citizenship">citizenship</a> <a href="https://www.diigo.com/user/coolcatteacher/permissions">permissions</a> <a href="https://www.diigo.com/user/coolcatteacher/digital_responsibilities">digital_responsibilities</a></p> </li> <li> <p class="diigo-link"> <a href="http://voices.yahoo.com/digital-photography-lessons-high-school-classes-11779016.html">Digital Photography Lessons for High School Classes - Yahoo! Voices - voices.yahoo.com</a> </p> <p class="diigo-description">Some interesting lessons for teaching photography with students in high school classes. I like to use photos on flickr as we discuss the rule of thirds, and other techniques. </p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/photography">photography</a> <a href="https://www.diigo.com/user/coolcatteacher/technology">technology</a></p> </li> <li> <p class="diigo-link"> <a href="http://www.guide2digitallearning.com/teaching_learning/10_ways_use_avatars_education">10 Ways To Use Avatars In Education | Digital Learning Environments</a> </p> <p class="diigo-description">If you can't use photos, avatars are a great replacement. Here are some suggestions for how to use avatars.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/education">education</a> <a href="https://www.diigo.com/user/coolcatteacher/avatars">avatars</a> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/digital">digital</a> <a href="https://www.diigo.com/user/coolcatteacher/citizenship">citizenship</a></p> </li> <li> <p class="diigo-link"> <a href="http://school.discoveryeducation.com/schooladventures/slavery/">Understanding Slavery - Learning Adventures</a> </p> <p class="diigo-description">Discovery Education has a set of resources covering this topic that will have some things you can use as part of Black History Month including teacher tips and resources.</p> <p class="diigo-tags"> <span>tags:</span> <a href="https://www.diigo.com/user/coolcatteacher/blackhistory">blackhistory</a> <a href="https://www.diigo.com/user/coolcatteacher/teaching">teaching</a> <a href="https://www.diigo.com/user/coolcatteacher/sschat">sschat</a> <a href="https://www.diigo.com/user/coolcatteacher/tumblr">tumblr</a></p> </li> </ul><p class="diigo-ps">Posted from <a href='https://www.diigo.com'>Diigo</a>. The rest of my favorite links are <a href='https://www.diigo.com/user/coolcatteacher'>here</a>.</p>

Teach This! Teaching with lesson plans and ideas that rock 02/17/2013

Totally Free Commercial Use Images ✔ The Ultimate Photo Resource Guide As students work on projects,...

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'SNL' Scorecard: Christoph Waltz Hosts The Best Show Of The Season

<div dir="ltr" style="text-align: left;" trbidi="on"><span style="background-color: white; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px;">  </span><img alt="christoph waltz snl" src="http://i.huffpost.com/gen/995641/original.jpg" style="background-color: white; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px;" /><br /><br /><div class="float_left" style="background-color: white; border: none; float: left; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px; list-style: none; margin: 0px; padding: 0px;"><a href="http://www.huffingtonpost.com/mike-ryan" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;"><img alt="Mike Ryan" height="45" src="http://s.huffpost.com/contributors/mike-ryan/headshot.jpg" style="border: none; float: left; list-style: none; margin: 0px; padding: 0px; text-align: center; vertical-align: baseline;" width="45" /></a></div><div class="float_left fixed_width_author" style="background-color: white; border: none; float: left; font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 12px; line-height: 16px; list-style: none; margin: 0px; padding: 0px; width: 195px;"><h2 style="border: none; float: left; list-style: none; margin: 0px 0px 0px 8px; padding: 0px;"><a href="http://www.huffingtonpost.com/mike-ryan" rel="author" style="border: none; color: #760101; cursor: pointer; font-family: Arial, Century, Times, serif !important; font-size: 20px !important; height: inherit; letter-spacing: 0.05em; line-height: 24px !important; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;">Mike Ryan</a></h2><div class="teaser_permalink" style="border: none; clear: both; float: left; font-size: 11px !important; font-style: italic !important; line-height: 11px !important; list-style: none; margin-bottom: 4px !important; margin-left: 7px !important; margin-top: 4px !important; padding: 0px; width: 180px;">Senior Entertainment Writer, The Huffington Post</div><div class="teaser_permalink" style="border: none; clear: both; float: left; font-size: 11px !important; font-style: italic !important; line-height: 11px !important; list-style: none; margin-bottom: 4px !important; margin-left: 7px !important; margin-top: 4px !important; padding: 0px; width: 180px;"></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;">oK, yes, I have calmed down from last week's disaster of a show. Order has been restored. Not only did an actual <i style="border: none; list-style: none; margin: 0px; padding: 0px;">actor</i> host "SNL" this week -- after back-to-back shows featuring musical artists as the host -- an <i style="border: none; list-style: none; margin: 0px; padding: 0px;">Academy Award-winning</i> actor hosted. Oh, and, strangely, there was not one sketch in which Christoph Waltz played himself, like we have seen, lazily, with the hosts as of late. (Though, Waltz did play both the pope <i style="border: none; list-style: none; margin: 0px; padding: 0px;">and</i> Jesus.) Enough with the negative! Waltz was fantastic, which resulted in the best show of the season. Waltz is the type of actor who can do almost anything and it felt like there was a lot of saved up material, just waiting for a host that could do almost anything. On to a rejuvenated Scorecard!</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;"><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">Sketch(s) of the Night</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px; text-align: center;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"What Have You Become Game Show"</strong> (Christoph Waltz, Kenan Thompson, Bill Hader, Aidy Bryant) Along with the cold open, this was the second time that Alabama got a mention tonight. Admittedly, I was worried when I saw this was a game show sketch. Yes, there have been great game show sketches over the years, but "SNL" has a tendency to sleepwalk through these types of things, too. Instead, the format is turned on its ear as each formerly happy contestant is asked what he or she had done with his or her individual life. The best part was the depressing theme music that played as each contestant, then host, gave their answers. "What Have You Become Game Show" is one of the best sketches of this season.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=b9ib1h9yewagz-3ashl91w&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score 9.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"New Tarantino Movie"</strong> (Christoph Waltz, Taran Killam, Jay Pharoah) A fake movie trailer for the new Tarantino revenge film, "Djesus Uncrossed," with blurbs from critics that include, "I never knew how much Jesus used the n-word" and dialogue like "The H is silent." Honestly, I can't remember the last time I debated this much over sketch of the night. So, screw it, it's my scorecard and if I want two sketches of the night, there can be two sketches of the night. It was just <strong style="border: none; list-style: none; margin: 0px; padding: 0px;">that</strong> solid of a show. (And I always love Killam's Brad Pitt.) Honestly, for a lot of reasons, I can't believe this even aired. It's nice to see "SNL" test the limits.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=c58yzofllrerzs1t6cvz7a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score 9.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Good</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Retirement Ad"</strong> (Christoph Waltz, Jason Sudeikis) Remember a few weeks ago when "SNL" aired the commercial parody for the home Starbucks machine -- and the gist was that the machine would get the owners name wrong ... then the sketch just kept going <i style="border: none; list-style: none; margin: 0px; padding: 0px;">and going</i> for no apparent reason? The joke was over. I was reminded of that while watching this because the Pope's retirement could have <i style="border: none; list-style: none; margin: 0px; padding: 0px;">easily</i> been a one-note joke, too. Yet, here, it was made into a retirement firm narrative that<i style="border: none; list-style: none; margin: 0px; padding: 0px;">ended</i> with the best joke about no other testimonials available.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=sifch4v12z8wwg58vyebwg&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 8.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Weekend Update"</strong> (Seth Meyers, Taran Killam, Kate McKinnon, Jay Pharoah) It's interesting, because it was evident on Seth Meyer's face that he knew that "SNL" was having a good night. And, thankfully, "Update" came out strong, too, with <i style="border: none; list-style: none; margin: 0px; padding: 0px;">three</i> segments. I have no idea what the crossover audience is for "SNL" and people who know who Stephen A. Smith is, but, boy, Pharoah's Stephen A. Smith is pretty fantastic. Also, I've <i style="border: none; list-style: none; margin: 0px; padding: 0px;">never</i> seen Pharoah break character, but if he didn't <em style="border: none; list-style: none; margin: 0px; padding: 0px;">fully</em> break last night, he came <i style="border: none; list-style: none; margin: 0px; padding: 0px;">really</i> close. Kate McKinnon and Seth Meyers seemed to be having the time of their lives with her "person who saw the Russian meteor" character. And it looks like Taran Killam will be taking on the role of Marco Rubio (good grief, I hope Killam's "parched Rubio voice" remains part of the impression forever), which <i style="border: none; list-style: none; margin: 0px; padding: 0px;">might</i> be tough once the Republican primaries start, considering he also plays Paul Ryan.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=ea2jyee9yr9ogiz9-boy1a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.8</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Jamarcus Brothers"</strong> (Christoph Waltz, Taran Killan, Cecily Strong, Kenan Thompson, Jay Pharoah) I wish the Jamarcus Brothers would have played "Where does my penis go, point to where" during this sketch. You know, with a lesser host, this could have been ... not great. But the chemistry between Pharoah and Thompson, with Waltz as their oddball third brother of the musical trio, wound up hitting.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=p2gcjjzqlnq38ogx1erfja&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.4</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Cold Open: Cruise Ship"</strong> (Jason Sudeikis, Cecily Strong, Jay Pharoah, Tim Robinson, Bobby Moynihan, Fred Armisen) This is perhaps the most depressing sketch "SNL" has ever aired. Not that it wasn't funny, but, <i style="border: none; list-style: none; margin: 0px; padding: 0px;">boy</i> this has been a lousy week as far as news goes -- which this sketch keenly reminded us. In other words: Instead of being a one-note sketch about the Poop Cruise, it was used as a way to address most of the recent (depressing) news items of the week. And it was nice seeing Cecily Strong playing a character that doesn't have some sort of "funny voice." Also, even though his monkey was eaten, I hope this isn't the last time we see Moynihan's Dan the Animal Man.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=0cwr2rq-jidcxlufelqrlg&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 7.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Secret Admirer Letter"</strong> (Christoph Waltz, Cecily Strong, Jason Sudeikis, Bill Hader, Kenan Thompson, Vanessa Bayer) It feels like it's been a few weeks since we had a truly bizarre 10 to 1 sketch. I'm not sure that "Secret Admirer Letter' qualifies as "bizarre," but you know what? Close enough. If nothing else, it featured a half naked Christoph Waltz leaning against a Ferrari.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=ovzmxbdndgni7sv5hy6nlq&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.6</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Christoph Waltz Monologue"</strong> (Christoph Waltz, Kate McKinnon, Bobby Moynihan, Taran Killam, Nasim Pedrad, Cecily Strong, Fred Armisen) Wow, I never thought I'd ever laugh at something called "Casual Hitler." This was a fairly good monologue because it showed that Waltz came with a level of, well, talent for acting in front an audience that we hadn't seen in a few <i style="border: none; list-style: none; margin: 0px; padding: 0px;">long</i>weeks. And it was nice to see a good amount of the cast get involved, which was a sign of things to come for the entire evening.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=jnntb2bumyh8boj_1e0v_a&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Tippy"</strong> (Nasim Pedrad, Christoph Waltz, Bobby Moynihan, Tim Robinson, Vanessa Bayer, Kate McKinnon, Kenan Thompson, Bobby Moynihan) Yes, Nasim Pedrad has played this type of "annoying, know-it-all" character before, but this is the first time that I can remember it not being a boy or a young child. Granted, perhaps it was the general good will from the quality of the rest of the show, but I laughed quite often during "Tippy." And, yes, it was <em style="border: none; list-style: none; margin: 0px; padding: 0px;">really</em> nice to see Pedrad be a major part of the show.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=tpxpadkl7pxmfkme76znra" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 6.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Bad</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Fox and Friends: 2013 State of the Union"</strong> (Taran Killam, Bobby Moynihan, Vanessa Bayer, Bill Hader, Fred Armisen) It was weird, I initially enjoyed last night's edition of "Fox and Friends" because I always enjoy "Fox and Friends." But I think my initial delight might have just been a result of the always great list of corrections. ("Zero Dark Thirty is not a diet soda.") Re-watching this morning, this was one of the weaker "Fox and Friends" installments -- which might be why it was relegated to the end of the show, as opposed to its usual spot in the cold open.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe allowfullscreen="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=gyo6l-gf6uf5y7b1alyoiq&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 5.5</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" /><b style="border: none; list-style: none; margin: 0px; padding: 0px;"><u style="border: none; list-style: none; margin: 0px; padding: 0px;">The Ugly</u></b></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">"Regine"</strong> (Christoph Waltz, Fred Armisen, Bill Hader, Vanessa Bayer, Aidy Bryant, Tim Robinson, Taran Killam) Oh, Regine, we were having such a nice evening before you showed up. The sentence before this one is how both the other characters in the sketch felt and how the audience at home felt watching. I mean, look, compared to what aired in past weeks, Regine would have been borderline <i style="border: none; list-style: none; margin: 0px; padding: 0px;">fine</i>. But our standards are just a little higher for this particular show and getting a glimpse of Fred Armisen's scrotum doesn't quite cut it this week.</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe br="" frameborder="0" height="350" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=vp6ehyz8cyp6dl33d2_cna&partner=aol" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" webkitallowfullscreen="" width="570"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Score: 4.0</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">Average Score for this Show: 7.03</strong></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><strong style="border: none; list-style: none; margin: 0px; padding: 0px;">· Christoph Waltz 7.03</strong><br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-martin-short_b_2311527.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Martin Short</a> 6.28<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-christina-applegate_b_1964996.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Christina Applegate</a> 6.13<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-seth-macfarlane_b_1887952.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Seth MacFarlane</a> 5.93<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-louis-ck_b_2072353.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Louis C.K.</a> 5.92<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-anne-hathaway_b_2113837.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Anne Hathaway</a> 5.87<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-bruno-mars_b_1997270.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Bruno Mars</a> 5.81<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-adam-levine_b_2561689.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Adam Levine</a> 5.71<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-joseph-gordon-levitt_b_1907329.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Joseph Gordon-Levitt</a> 5.51<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jamie-foxx_b_2267347.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jamie Foxx</a> 5.43<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jeremy-renner_b_2154730.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jeremy Renner</a> 5.39<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-jennifer-lawrence_b_2516152.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Jennifer Lawrence</a> 5.38<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-daniel-craig_b_1946309.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Daniel Craig</a> 5.35<br style="border: none; display: block; list-style: none; margin: 0px 0px 4px; padding: 0px;" />· <a href="http://www.huffingtonpost.com/mike-ryan/snl-scorecard-justin-bieber_b_2657680.html" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Justin Bieber</a> 5.23</div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><em style="border: none; list-style: none; margin: 0px; padding: 0px;">Mike Ryan is senior writer for Huffington Post Entertainment. You can contact him <a href="http://twitter.com/mikeryan" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_blank">directly on Twitter.</a> Click below for this week's "SNL," Not Ready For Primetime Podcast featuring Mike Ryan and Hitfix's <a href="https://twitter.com/TVMcGee" style="border: none; color: #b10000; cursor: pointer; list-style: none; margin: 0px; outline: none; padding: 0px; text-decoration: none;" target="_hplink">Ryan McGee.</a></em></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin-bottom: 14px; padding: 0px;"><iframe height="240" scrolling="no" src="http://html5-player.libsyn.com/embed/episode/id/2221260/height/240/width/427/theme/legacy/direction/no/autoplay/no/autonext/no/thumbnail/yes/preload/no/no_addthis/no/" style="border-style: none; list-style: none; margin: 0px; padding: 0px;" width="427"></iframe></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin: 0px; padding: 0px;"></div><div style="border: none; font-family: Georgia, Century, Times, serif; font-size: 13px; font-style: normal; line-height: 20px; list-style: none; margin: 0px; padding: 0px;"></div><div class="clear full" style="border: none; clear: both; font-family: Georgia, Century, Times, serif; font-size: 1px; font-style: normal; height: 8px; line-height: 1px !important; list-style: none; margin: 0px; overflow: hidden !important; padding: 0px;"> </div></div></div>

'SNL' Scorecard: Christoph Waltz Hosts The Best Show Of The Season

   Mike Ryan Senior Entertainment Writer, The Huffington Post oK, yes, I have calmed down from last week's disaster of a show. Order has...

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Harvick holds off Biffle to win NASCAR Sprint Unlimited

<div dir="ltr" style="text-align: left;" trbidi="on"><div dir="ltr" style="text-align: left;" trbidi="on"><br /></div><iframe allowfullscreen="" frameborder="0" height="360" src="http://www.youtube.com/embed/8I7-SB6pCHA?feature=player_detailpage" width="640"></iframe><br /><div dir="ltr" style="text-align: left;" trbidi="on"><div dir="ltr" style="text-align: left;" trbidi="on"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Jeff Gluck, USA TODAY Sports</span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; 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color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><br /></span><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"></span><br /><h2 class="lead-in" style="font-family: arial, sans-serif; font-size: 18px; font-style: italic; font-weight: normal; line-height: 27px; margin-left: 60px; margin-top: -2px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">It only took 15 laps for a demolition derby to begin in Saturday night's Sprint Unlimited.</span></h2><div class="article-metadata-wrap" style="float: left; font-size: 16px; font-weight: normal; height: auto; line-height: 22px; margin: 0px 30px 0px 60px; position: relative;"><aside class="single-photo expandable-collapsed" itemprop="associatedMedia" itemscope="" itemtype="http://schema.org/ImageObject" style="clear: left; float: left; margin-bottom: 20px; position: relative; width: 180px; z-index: 100;"><div class="image-wrap" style="box-shadow: rgb(200, 200, 200) 1px 1px 5px; cursor: pointer; padding: 3px; position: relative;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><img alt="2-16-2013 kevin harvick victory lane" class="expand-img-horiz" itemprop="url" src="http://www.gannett-cdn.com/media/USATODAY/USATODAY/2013/02/16/2-16-13-harvick-celebrates-4_3_r536_c534.jpg?1b79b3da202957124496e3768cfb7b67cdb10c81" style="border: 0px; max-width: 100%; min-height: 131px; vertical-align: middle;" /><span class="toggle" style="background-image: url(http://www.gannett-cdn.com/static/images/sprites/asset-sprite.png); background-position: 0% 0%; background-repeat: no-repeat no-repeat; bottom: 0px; height: 21px; position: absolute; right: 0px; width: 21px; z-index: 200;"></span></span></div><div class="image-credit-wrap" style="color: #646464; font-family: arial, sans-serif; font-size: 11px; font-weight: 700; line-height: 16px; margin-top: 6px; padding: 0px 5px 0px 0px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><span class="credit" style="font-style: italic; font-weight: 400;">(Photo: Kevin Liles, USA TODAY Sports)</span></span></div></aside><div class="article-metadata" style="position: relative;"><aside class="comp story-highlights " style="clear: left; float: left; margin: 0px 0px 20px; min-height: 60px; width: 180px;"><h3 class="hlts" style="border-bottom-color: rgb(212, 212, 212); border-bottom-style: dotted; border-bottom-width: 1px; color: #999999; font-family: 'Futura Today Bold', arial, sans-serif; font-size: 12px; font-weight: 400; line-height: 25px; margin: 0px auto; text-transform: uppercase;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">STORY HIGHLIGHTS</span></h3><ul class="hlt" style="color: #333333; font-family: arial, sans-serif; font-size: 14px; left: 0px; list-style: none; margin: 0px; padding: 0px; position: relative;"><li class="hlt-item" style="background-image: url(http://www.gannett-cdn.com/static/images/components/story_highlights_bullets.png); background-position: 0px 17px; background-repeat: no-repeat no-repeat; border-bottom-color: rgb(212, 212, 212); border-bottom-style: dotted; border-bottom-width: 1px; color: #646464; font-size: 12px; font-weight: bold; line-height: 16px; padding: 12px 0px 12px 15px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Kevin Harvick won the race formerly known as the Budweiser Shootout for the third time</span></li><li class="hlt-item" style="background-image: url(http://www.gannett-cdn.com/static/images/components/story_highlights_bullets.png); background-position: 0px 17px; background-repeat: no-repeat no-repeat; border-bottom-color: rgb(212, 212, 212); border-bottom-style: dotted; border-bottom-width: 1px; color: #646464; font-size: 12px; font-weight: bold; line-height: 16px; padding: 12px 0px 12px 15px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Tony Stewart triggered an early crash just 15 laps into the three-segment race</span></li><li class="hlt-item" style="background-image: url(http://www.gannett-cdn.com/static/images/components/story_highlights_bullets.png); background-position: 0px 17px; background-repeat: no-repeat no-repeat; border: 0px; color: #646464; font-size: 12px; font-weight: bold; line-height: 16px; padding: 12px 0px 12px 15px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Jimmie Johnson, Denny Hamlin, Jeff Gordon and Kyle Busch were among those collected</span></li></ul></aside></div></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">DAYTONA BEACH, Fla. — Most people think Kevin Harvick's lame duck season at Richard Childress Racing will limit his success.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Harvick and his No. 29 team beg to differ; they think it's unlimited.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">NASCAR's season-opening Sprint Unlimited exhibition race went to Harvick on Saturday night, the third time he's won the race formerly known as the Shootout in the last five years. Harvick is leaving RCR for Stewart-Haas Racing after this season.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"I don't think it's been that big of a deal," Harvick said of his situation. "...Our guys, they don't care. They just want to win."</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><b>RESULTS: </b><a href="http://sportsdirect.usatoday.com/motorsports/nascar/nascar-races.aspx?page=/data/nascar/results/2013/race985.html" style="color: #1990e5; text-decoration: none;" title="http://sportsdirect.usatoday.com/motorsports/nascar/nascar-races.aspx?page=/data/nascar/results/2013/race985.html">Sprint Unlimited finish</a></span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><b>FIVE LESSONS: </b><a href="http://www.usatoday.com/story/sports/nascar/2013/02/17/sprint-unlimited-daytona-shootout-gen-6-nascar-car/1925491/" style="color: #1990e5; text-decoration: none;" title="http://www.usatoday.com/story/sports/nascar/2013/02/17/sprint-unlimited-daytona-shootout-gen-6-nascar-car/1925491/">What drivers learned in the Unlimited</a></span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">It was a special night for Harvick, who killed his engine trying to do a burnout and had to be pushed to Victory Lane. His son Keelan, who sat in his father's car and left a shoe in it before the race, performed his first forward crawl.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">​Confident his team will be able to stay together in a potentially awkward situation, Harvick said the group is "going to have a helluva lot of fun racing, having a good time, doing our jobs.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"The atmosphere is great, honestly," he said.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Crew chief Gil Martin, buoyed by the exhibition victory and a promising start to the new season, vowed to do "whatever it takes" to win the championship this season.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Anyone who thinks otherwise, he said, is "sadly mistaken."</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"Pride also comes in there pretty good, too," Harvick chimed in. "It's fun to prove people wrong."</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Harvick quieted the lame duck talk -- at least for a night -- with a bold move to block Greg Biffle's last-lap charge.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Biffle had a big boost of momentum on the high side, but Harvick just kept drifting up until the Roush Fenway Racing driver backed off. The mirror-driving gave Harvick a clean path to the finish line.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Harvick, who once flipped his go-kart in a backyard race because he was unwilling to cede the position, said he had no thoughts of lifting off the gas.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><b>PHOTOS: </b><a href="http://www.usatoday.com/picture-gallery/sports/nascar/2013/02/15/nascar-sprint-unlimited-practice/1923939/" style="color: #1990e5; text-decoration: none;" title="http://www.usatoday.com/picture-gallery/sports/nascar/2013/02/15/nascar-sprint-unlimited-practice/1923939/">Friday's Unlimited practice</a></span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"When you're coming from white to checkered, it's whatever you have to do to try to make it happen," he said. "I guess a game of 'chicken' would be the best way to put it."</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Said Biffle: "I had a run on him on the top there, and he kind of closed the door. Kevin did what he had to do to win that race. I didn't think there was room to stick it in there; I thought we would end up wrecked."</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Though Harvick led 40 of the final 42 laps in a relatively tame race, a big wreck marred the first segment and took out several contenders.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Tony Stewart came across Marcos Ambrose's nose at the exit of Turn 1 on lap 15 and got out of shape, but was able to save it. When his car started to spark, though, a three-wide group of drivers behind him wiggled and collided, triggering a crash.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Jimmie Johnson, Denny Hamlin, Jeff Gordon, Mark Martin, Kurt Busch and Kyle Busch — last year's winner — were all collected in the crash. That left just 12 cars on the track for the rest of the night.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"I self-cleared myself, I guess," Stewart said. "I went down before the spotter cleared me. I thought I had a big enough run that I cleared second, but I obviously hadn't and I just barely nicked him. I just needed about two more inches."</span></div><aside class="wide single-photo" itemprop="associatedMedia" itemscope="" itemtype="http://schema.org/ImageObject" style="clear: left; float: none; font-size: 16px; font-weight: normal; line-height: 22px; margin-bottom: 20px; margin-left: 60px; margin-top: 25px; width: auto;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><img alt="None" itemprop="url" src="http://www.gannett-cdn.com/media/USATODAY/USATODAY/2013/02/16/early-crash-4_3_r541_c540.jpg?729ef1a5e3c69f5da0197e57e2bd3dd3fdfcd35f" style="border: 0px; max-width: 100%; vertical-align: middle;" width="540" /><div style="color: #646464; font-family: arial, sans-serif; font-size: 11px; font-weight: 700; line-height: 16px; margin-top: 6px; padding: 0px 5px 0px 0px;">Denny Hamlin (11), Kyle Busch (18), Jeff Gordon (24) and Jimmie Johnson (48), are involved in multicar crash during the early stages of Saturday's Sprint Unlimited.<span class="credit" style="font-style: italic; font-weight: 400;">(Photo: Matthew Stockman, Getty Images)</span></div></span></aside><div class="clearfix" style="font-size: 16px; font-weight: normal; line-height: 22px;"></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">In general, it wasn't a very good night for Stewart. He also had a shot at the win, but couldn't quite figure out which move to make on the last lap.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"That is why I haven't won a Daytona 500 yet," he said.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Matt Kenseth dominated the opening segment, leading 25 of the 30 laps. But Stewart passed him on the final lap of Segment 1 to "win" the first portion of the race.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Harvick then took the lead after a pit stop and maintained it despite some shuffling in Segment No. 2.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">The Unlimited marked NASCAR's first test with its new Gen 6 cars — and there were plenty of unknowns. Thanks to wrecks in two separate test sessions when drivers attempted to draft, no one knew quite what to expect.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;"><a href="http://www.usatoday.com/story/sports/nascar/2013/01/20/sprint-unlimited-shootout-format-daytona-international-speedway/1849237/" style="color: #1990e5; text-decoration: none;" title="http://www.usatoday.com/story/sports/nascar/2013/01/20/sprint-unlimited-shootout-format-daytona-international-speedway/1849237/">Fans got to determine the format of the race</a>, which was three segments of 30 laps, 25 laps and 20 laps. They also voted for no eliminations to occur — though it didn't matter after the early wreck — and voted for a mandatory four-tire pit stop after the first segment.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Though some cars were torn up, race teams won't need to worry about whether they will have enough cars for the Daytona 500; the Sprint Unlimited cars are separate from the 500 fleet (which consist of both a primary car and a backup on standby).</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Furniture Row Racing, for example, is still good on cars despite wrecking two vehicles in two days. Richard Childress (whose team has an alliance with Furniture Row) said the organization has eight cars in Daytona and two spares at its North Carolina shop.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">The Unlimited took place on an unusually chilly night in Daytona Beach. Though it was 52 degrees at race time, the wind from an oncoming cold front made it feel much chillier.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Formerly known as the Shootout, the race consisted of drivers who had won poles in 2012. That meant defending Sprint Cup Series champion Brad Keselowski and runner-up Clint Bowyer had to watch the race from the sidelines.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Keselowski was a guest analyst for FOX's TV broadcast, and Bowyer initially said he wished he was in the race but was singing a different tune later.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">"I have changed my mind..." Bowyer tweeted after seeing the big wreck.</span></div><div style="color: #333333; font-family: arial, sans-serif; font-size: 14px; font-weight: normal; line-height: 22px; margin-bottom: 15px; margin-left: 60px;"><span class="asset-metabar-author asset-metabar-item" itemprop="name" style="background-color: white; color: #222222; float: left; font-family: Arial, sans-serif; font-size: 12px; font-weight: 700; line-height: 14px; margin: 6px 0px 5px; padding: 2px 10px; position: relative;">Carl Edwards was black-flagged for losing his driver's side net and finished 12th.</span></div></div></div></div>

NASCAR Harvick holds off Biffle to win NASCAR Sprint Unlimited

Jeff Gluck, USA TODAY Sports It only took 15 laps for a demolition derby to begin in Saturday night's Sprint Unlimited. (Photo: Kevin Li...

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Alabama Shakes Rock 'Always Alright' on 'SNL'

<div dir="ltr" style="text-align: left;" trbidi="on"><div dir="ltr" style="text-align: left;" trbidi="on"><span style="background-color: white; font-family: georgia; font-size: 12px;">Band brings Southern grooves to Studio 8H stage</span><span style="font-family: georgia; font-size: 12px; margin: 0px; padding: 0px;"><br style="margin: 0px; padding: 0px;" /></span></div><iframe allowfullscreen="" frameborder="0" height="288" mozallowfullscreen="" scrolling="no" src="http://www.hulu.com/embed.html?eid=zlrrg1wdhz1gfleoy15rvg&partner=edp&uri=http%3a%2f%2fwww.hulu.com%2fwatch%2f457667" webkitallowfullscreen="" width="512"></iframe><br /><br /><div class="storyAbstract" style="font-family: georgia; font-size: 12px; margin: 0px 0px 24px; padding: 0px;"><span class="byline" style="float: left; font-size: 16px; font-style: italic; margin: 4px 4px 0px 0px; padding: 0px;">By</span><div class="video-player-author" style="float: left; font-size: 15px; font-weight: bold; margin: 4px 0px 0px; padding: 0px; text-transform: uppercase;"><a href="http://www.rollingstone.com/contributor/rolling-stone" style="color: black; float: left; margin: 1px 0px 0px; padding: 0px; text-decoration: none;">ROLLING STONE</a></div></div><div class="video-player-datetime" itemprop="datePublished" style="clear: left; float: left; font-family: georgia; font-size: 12px; margin: 4px 0px 12px; padding: 0px; text-transform: uppercase;">FEBRUARY 17, 2013 11:35 AM</div><div class="video-player-video-description clearfix" itemprop="description" style="clear: both; font-family: georgia; font-size: 15px; margin: 0px; padding: 0px;"><div style="line-height: 1.5em; margin-bottom: 1em; padding: 0px;">Alabama Shakes took the stage on <em style="margin: 0px; padding: 0px;">Saturday Night Live</em> last night with a relatively calm physical presence standing in marked contrast to frontwoman Brittany Howard's fierce and howling vocals. The Grammy-nominated band started the night off with a relaxed take on "Hold On," the opening track of their debut album, <em style="margin: 0px; padding: 0px;">Boys & Girls</em>. For their second set, they returned to the stage with the gently rollicking rockabilly grooves of "Always Alright," giving Howard a chance to get a little wild with her Gibson.</div></div><span style="font-family: georgia; font-size: 12px; margin: 0px; padding: 0px;"><br style="margin: 0px; padding: 0px;" /><br style="margin: 0px; padding: 0px;" /></span></div>

Alabama Shakes Alabama Shakes Rock 'Always Alright' on 'SNL'

Band brings Southern grooves to Studio 8H stage By ROLLING STONE FEBRUARY 17, 2013 11:35 AM Alabama Shakes took the stage on  Saturday Night...

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Sudden-Onset Madness - Diagnosis - NYTimes.com

<base href="data:"><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><div class="nytmm_diagnosiscolumn_section" style="margin: 20px 0px 50px 18px; border-top-width: 2px; border-top-style: solid; border-top-color: rgb(0, 0, 0); position: relative; color: rgb(51, 51, 51); font-family: georgia, 'times new roman', times, serif; font-size: 10px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); "><h2 style="margin: 0px; color: rgb(0, 0, 0); font-size: 12px; line-height: 1.1em; position: absolute; display: block; width: auto; background-color: rgb(255, 255, 255); padding: 2px 10px; top: -8px; left: 30px; font-weight: bold; text-transform: uppercase; font-family: Arial, Helvetica, sans-serif; background-position: initial initial; background-repeat: initial initial; "><a name="Intro" style="color: rgb(0, 0, 0); text-decoration: none; ">A CRY FOR HELP</a></h2><div class="nytmm_diagnosiscolumn_section_content" style="margin-top: 20px; width: 465px; "><div class="nytmm_diagnosiscolumn_section_text"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">''Get me out of here!'' the middle-aged man shouted to his sister from his hospital bed. ''They're coming to get me.'' His eyes darted from side to side as if searching for someone who was after him. His arms and legs shook. She had never seen him like this. He looked terrified.</div></div></div></div><div class="nytmm_diagnosiscolumn_section" style="margin: 20px 0px 50px 18px; border-top-width: 2px; border-top-style: solid; border-top-color: rgb(0, 0, 0); position: relative; color: rgb(51, 51, 51); font-family: georgia, 'times new roman', times, serif; font-size: 10px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); "><h2 style="margin: 0px; color: rgb(0, 0, 0); font-size: 12px; line-height: 1.1em; position: absolute; display: block; width: auto; background-color: rgb(255, 255, 255); padding: 2px 10px; top: -8px; left: 30px; font-weight: bold; text-transform: uppercase; font-family: Arial, Helvetica, sans-serif; background-position: initial initial; background-repeat: initial initial; "><a name="fall" style="color: rgb(0, 0, 0); text-decoration: none; ">A TERRIBLE FALL</a></h2><div class="nytmm_diagnosiscolumn_section_content" style="margin-top: 20px; width: 465px; "><div class="nytmm_diagnosiscolumn_section_text"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">Three months earlier, the patient, a 55-year-old man who suffered from depression and alcoholism, was admitted to the same hospital after falling down the stairs in his home. He wasn't found for two, possibly three days. Because of his injuries and this delay, when he was discovered, he was close to death. His kidneys had stopped working, and his body chemistry was completely out of whack. On the way to the hospital, his heart stopped, and he had to be shocked back to life.</div></div></div></div><div class="nytmm_diagnosiscolumn_section" style="margin: 20px 0px 50px 18px; border-top-width: 2px; border-top-style: solid; border-top-color: rgb(0, 0, 0); position: relative; color: rgb(51, 51, 51); font-family: georgia, 'times new roman', times, serif; font-size: 10px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); "><h2 style="margin: 0px; color: rgb(0, 0, 0); font-size: 12px; line-height: 1.1em; position: absolute; display: block; width: auto; background-color: rgb(255, 255, 255); padding: 2px 10px; top: -8px; left: 30px; font-weight: bold; text-transform: uppercase; font-family: Arial, Helvetica, sans-serif; background-position: initial initial; background-repeat: initial initial; "><a name="recovery" style="color: rgb(0, 0, 0); text-decoration: none; ">A SLOW RECOVERY</a></h2><div class="nytmm_diagnosiscolumn_section_content" style="margin-top: 20px; width: 465px; "><div class="nytmm_diagnosiscolumn_section_text"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">The patient remained in Waterbury Hospital in Connecticut for five weeks (where I was one of his doctors), three of them in intensive care. Even after these weeks of care, the toll of his injury was terrible: his kidneys were still not working, so he required hemodialysis three times a week; his arms and legs were so weak that he could not even lift them. He was unable to swallow and had to be fed through a tube. When his sister visited him there, she barely recognized him. His slender body was bloated. He had tubes everywhere. He could do little more than whisper. Still, she saw that he was slowly improving. He had started to smile and make jokes despite his many disabilities. After five weeks in the hospital, he was transferred to a short-term rehabilitation facility.</div></div></div></div><div class="nytmm_diagnosiscolumn_section" style="margin: 20px 0px 50px 18px; border-top-width: 2px; border-top-style: solid; border-top-color: rgb(0, 0, 0); position: relative; color: rgb(51, 51, 51); font-family: georgia, 'times new roman', times, serif; font-size: 10px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); "><h2 style="margin: 0px; color: rgb(0, 0, 0); font-size: 12px; line-height: 1.1em; position: absolute; display: block; width: auto; background-color: rgb(255, 255, 255); padding: 2px 10px; top: -8px; left: 30px; font-weight: bold; text-transform: uppercase; font-family: Arial, Helvetica, sans-serif; background-position: initial initial; background-repeat: initial initial; "><a name="seeing" style="color: rgb(0, 0, 0); text-decoration: none; ">SEEING THINGS</a></h2><div class="nytmm_diagnosiscolumn_section_content" style="margin-top: 20px; width: 465px; "><div class="nytmm_diagnosiscolumn_section_text"><p style="margin: 0px 0px 1em; font-size: 14px; line-height: 20px; ">After two weeks in rehab, something changed. He started talking to people no one else could see. He feared they wanted to harm him. When the hallucinations persisted for a second day, he was sent to the emergency room at Waterbury.</p><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">The patient told the E.R. psychiatrist that he was seeing people he knew couldn't be there. Despite the hallucinations, he was calm and clear. He told the doctor that he thought the visions began after he recently started taking a new sleeping pill. That made sense to the doctor. Delirium is an unusual but known side effect of that drug. He put the patient on a different sleep medication and returned him to rehab.</div></div></div></div><div class="nytmm_diagnosiscolumn_section" style="margin-top: 20px; margin-right: 0px; margin-bottom: 50px; margin-left: 18px; border-top-width: 2px; border-top-style: solid; border-top-color: rgb(0, 0, 0); position: relative; color: rgb(51, 51, 51); font-family: georgia, 'times new roman', times, serif; font-size: 10px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); z-index: auto; "><h2 style="margin: 0px; color: rgb(0, 0, 0); font-size: 12px; line-height: 1.1em; position: absolute; display: block; width: auto; background-color: rgb(255, 255, 255); padding: 2px 10px; top: -8px; left: 30px; font-weight: bold; text-transform: uppercase; font-family: Arial, Helvetica, sans-serif; background-position: initial initial; background-repeat: initial initial; "><a name="delirium" style="color: rgb(0, 0, 0); text-decoration: none; ">DELIRIUM</a></h2><div class="nytmm_diagnosiscolumn_section_content" style="margin-top: 20px; width: 465px; "><div class="nytmm_diagnosiscolumn_section_text"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">Two days later he was back. He was still seeing people who weren't there, but now he was also frantic and confused. He knew his name but little more. All he was certain of was that he was in danger. Because of his confusion, Dr. Brian Linde, the intern on call, couldn't rely on the patient to tell his own story. Instead the doctor had to depend on the patient's records to make sense of the situation in front of him: the hospital notes provided an outline of the patient's earlier admissions. The rehab-center records showed some details of his recovery from the serious injury. It also included a long list of the medications he was taking and reported that he had been confused for the past four days. On examination, the patient had a fever. His heart was racing, and his blood pressure was high. His arms and legs were weak and swollen. His legs were shaking, and his muscles were hyperreactive.</div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font-size: 14px; line-height: 20px; ">More ...</div></div></div></div></div><a href="http://www.nytimes.com/interactive/2013/02/17/magazine/diagnosis-sudden-onset-madness.html?ref=todayspaper#/#seeing">http://www.nytimes.com/interactive/2013/02/17/magazine/diagnosis-sudden-onset-madness.html?ref=todayspaper#/#seeing</a><div style="font-family: Helvetica; font-size: 14px; color: black; text-align: left; "><br class="webkit-block-placeholder"></div>

Sudden-Onset Madness - Diagnosis - NYTimes.com

A CRY FOR HELP ''Get me out of here!'' the middle-aged man shouted to his sister from his hospital bed. ''They'r...

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